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中文摘要
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我们的工作集中在表征认知的各个方面, 精神分裂症的失败 我们特别努力: 1.检查记忆功能。 目前正在进行研究, 启动过程中的远距或自传体记忆和内隐记忆 范例 其他的研究包括使用 不同干扰条件下的Parson Petersen范式。 2.检查特异性。 我们在评估双胞胎的认知功能 不符合情感障碍,双胞胎不符合精神分裂症, 颞叶癫痫、创伤性脑损伤(NRH)和情感性 disorder. 3.检查执行功能。 一些任务涉及延迟 反应和老年学习的发展, 在PET中用作认知激活剂, SPECT。 4.以检验精神抑制剂的效果。 我们在比较病人的 在接受神经心理测试时的表现 氯氮平氟哌啶醇和安慰剂 5.去检查航线。 我们正在评估精神分裂症和躁郁症 患者的横断面设计和精神分裂症患者在一个 纵向设计 6.研究认知增强策略。 我们正在研究 安非他明对注意力和执行任务的影响。 7.为了研究运动障碍、认知障碍和认知障碍之间的关系, 损伤和精神病理学。 我们正在集中评估同卵双胞胎 在神经心理学、精神病理学和核磁共振成像上都有 迟发性运动障碍和肌张力障碍患者。 8.检验认知与精神病理学的关系。 查普曼 快感缺乏、知觉偏差和魔法思维的量表提供了 确定大脑和大脑之间有意义关系的可能性 异常和心理异常。
英文摘要
Our work has focused on characterizing various facets of cognitive failure in schizophrenia. We have attempted in particular: 1. To examine memory function. Studies are underway which are examining remote or autobiographical memory and implicit memory in a priming paradigm. Other studies involve assessing working memory using the Parson Petersen paradigm with different interference conditions. 2. To examine specificity. We are assessing cognitive functions in twins discordant for affective disorder, twins discordant for schizophrenia, temporal lobe epilepsy, traumatic brain injury (at NRH), and affective disorder. 3. To examine executive function. A number of tasks that involve delayed response and senile learning have been developed both to ascertain performance profiles and to be used as cognitive activators in PET and SPECT. 4. To examine the effects of neuroleptics. We are comparing patients' performance on neuropsychological tests while they am receiving clozapine, haloperidol, and placebo. 5. To examine course. We are assessing schizophrenic and bipolar patients in cross-sectional designs and schizophrenic patients in a longitudinal design. 6. To examine cognitive enhancing strategies. We are examining the effects of amphetamine on attentional and executive tasks. 7. To examine the relation between movement disorder, cognitive impairment, and psychopathology. We are intensively assessing MZ twins with Tourette's syndrome on neuropsychology, psychopathology, and MRI and patients with Tardive dyskinesia and dystonia. 8. To examine the relation to cognition to psychopathology. The Chapman Scales of anhedonia, perceptual aberration, and magical ideation offer the possibility of ascertaining meaningful relations between brain abnormalities and psychological abnormalities.
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CHARACTERIZATION OF NEUROPSYCHOLOGICAL IMPAIRMENT IN SCHIZOPHRENIA
CHARACTERIZATION OF NEUROPSYCHOLOGICAL IMPAIRMENT IN SCHIZOPHRENIA
CHARACTERIZATION OF NEUROPSYCHOLOGICAL IMPAIRMENT IN SCHIZOPHRENIA
DEVELOPMENT OF COGNITIVE ACTIVATION TASKS FOR FUNCTIONAL NEUROIMAGING
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