PSYCHOBIOLOGY AND TREATMENT OF PERI-MENOPAUSAL MOOD DISORDERS

围绝经期情绪障碍的心理生物学和治疗

• 批准号: 3759465
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3759465
• 关键词: depression; endocrine pharmacology; estrogens; female; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; marriage /marital status; menopause; mental disorder chemotherapy; mood disorders; psychobiology; psychological stressor; psychopharmacology; sign /symptom

The goals of this project are to detect and accurately describe perimeno- pausal mood disorders, explore their pathophysiology and response to pharmacological and environmental manipulation, and document the rela- tionship between reproductive endocrine change and disorders of mood as a way of further investigating the neurobiology of psychiatric illness. Findings to date include the following. 1) Evidence of hot flushes. 2) Demonstration of the resolution of mood and hot flush symptoms in peri- menopausal women following spontaneous resolution of normal ovarian function. 3) Prospective demonstration of the appearance of mood symp- toms in association with declining ovarian function. 4) Identification of increased negative life events and increased marital discord, but similar numbers of exit events in peri-menopausal depressed women com- pared with peri-menopausal controls.

该项目的目标是检测和准确描述perimeno- 暂停情绪障碍，探讨他们的病理生理和反应， 药理学和环境操作，并记录相关的 生殖内分泌改变与情绪障碍的关系 进一步研究精神疾病的神经生物学的方法。 迄今为止的调查结果包括以下内容。 1)有潮热的迹象。 （二） 证明情绪和潮热症状的解决， 正常卵巢功能自然消退后的绝经期妇女 功能 3)情绪症状出现的前瞻性演示- 与卵巢功能下降有关。 4)识别 消极生活事件和婚姻不和的增加， 在围绝经期抑郁妇女中， 与围绝经期对照。