PSYCHOBIOLOGY AND TREATMENT OF MENSTRUALLY-RELATED MOOD DISORDERS

心理生物学和月经相关情绪障碍的治疗

• 批准号: 3921854
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3921854
• 关键词: alprazolam; clonidine; cognition disorders; female; gonadotropins; hormone regulation /control mechanism; human subject; human therapy evaluation; hypoglycemia; longitudinal human study; menstrual cycle; menstrual cycle disorder; mental disorder diagnosis; mood disorders; neuroendocrine system; premenstrual syndrome; psychobiology; psychosomatic disorders; sex hormones; sleep; thyroid function

The occurrence of dramatic changes in mood, behavior, cognition and somatic functioning in some women in relation to the menstrual cycle has recently been the focus of a great deal of public scrutiny. This project is designed to study the psychobiology and treatment response of women with well-defined menstrually-related mood disorders. The longitudinal screening methods developed by this group are capable of distinguishing women with menstrually- related mood syndromes from those who only believe that they have such a syndrome. With these methods, we have identified the following: 1) the occurrence of the characteristic premenstrual ;syndrome state during an antiprogestin-induced follicular phase; 2) a reduction of PMS symptoms during clonidine infusion; 3) menstrual cycle phase-dependent changes in perception of cognitive performance in patients with menstrually-related mood disorders but not controls; 4) a lack of relationship between self- ratings of fatigue and sleep characteristics, but a positive correlation between self-ratings of mood and fatigue; 5) evidence of abnormal basal thyroid measures in 10% of patients with PMS. The goals of this project are to detect and accurately describe menstrually-related mood disorders, explore their pathophysiology and response to pharmacological and environmental manipulation, and to document the relationship between reproductive endocrine change and disorders of mood as a way of further investigating the neurobiology of psychiatric illness.

情绪、行为、认知发生剧烈变化 和身体功能在一些妇女与月经 最近，一个周期已经成为公众关注的焦点。 审查 该项目旨在研究心理生物学， 患有明确月经相关疾病的女性的治疗反应 情绪障碍 纵向筛选方法由 这群人能够区分女性和男性- 相关的情绪综合征，从那些谁只相信他们有 这样的综合症。 通过这些方法，我们确定了 以下：1）发生特征性经前 抗孕激素诱导卵泡期的综合征状态; 2)可乐定输注期间PMS症状减轻; 3） 月经周期时相依赖的认知变化 与精神病相关情绪患者的表现 （4）缺乏自我控制;（5）缺乏自我控制。 疲劳和睡眠特征的评级，但积极的 情绪自评与疲劳之间的相关性; 5）证据 10%的PMS患者的基础甲状腺指标异常。 该项目的目标是检测和准确描述 精神相关的情绪障碍，探索其病理生理学 以及对药理学和环境操作的反应， 来记录生殖内分泌变化 和情绪障碍作为进一步调查 精神疾病的神经生物学