HORMONAL STUDIES OF AFFECTIVE DISORDER

情感障碍的荷尔蒙研究

• 批准号: 3921855
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3921855
• 关键词: AIDS; Alzheimer's disease; blood brain barrier; caffeine; carbamazepine; cerebellar cortex; cerebrospinal fluid; clinical chemistry; cortisol; hormone regulation /control mechanism; human subject; interleukin 2; laboratory rat; mental disorder chemotherapy; messenger RNA; mood disorders; neuroendocrine system; neuropsychological tests; neuropsychology; neurotoxins; pituitary adrenal axis; progesterone; psychophysiology; psychotropic drugs; somatostatin

Studies of somatostatin and cortisol in relation to affective and other neuropsychiatric disorders have continued. Additionally, other studies have been undertaken including the investigation of progesterone in women with a variety of affective syndromes, beta endorphin in humans and rats administered interleukin-2 (IL-2), dehydroepiandrosterone-sulfate in Alzheimer's and AIDS patients, and pituitary cell culture response to IL-2. A) Somatostatin - In human post-mortem regional brain studies, no difference in concentration of somatostatin was observed in the hippocampus, amygdala, or prefrontal region among schizophrenics, suicides, and controls. Post-mortem CSF studies showed significantly increased ventricular CSF somatostatin in Parkinson's and Huntington's patients compared with controls or Alzheimer's patients. B) Cortisol - Salivary cortisol has been used to study patients and controls undergoing caffeine infusion, patients on carbamazepine, and patients with affective disorder, on a longitudinal basis. C) Other assay measures - Assays for plasma beta-endorphin, salivary progesterone; and CSF DHEAS have been developed to study IL-2 and menses-related affective changes, as well as AIDS and Alzheimer's disease.

生长抑素和皮质醇与情绪和行为的关系 其他神经精神疾病仍在继续。 此外，本发明还 还进行了其他研究，包括调查 孕激素在各种情感综合征妇女中的作用， 给予白细胞介素-2（IL-2）的人和大鼠中的内啡肽， 脱氢表雄酮硫酸盐在阿尔茨海默氏症和艾滋病患者， 和垂体细胞培养物对IL-2的应答。 A）生长抑素-在人类死后局部脑研究中，没有 生长抑素浓度的差异，观察到在 海马体、杏仁核或前额区， 自杀和对照组 死后脑脊液检查显示 帕金森氏症患者脑室CSF生长抑素显著增加 和亨廷顿病患者与对照组或阿尔茨海默病患者相比， 患者 B）皮质醇-唾液皮质醇已被用于研究患者 对照组接受咖啡因输注， 卡马西平和情感障碍患者， 纵向基础。 C）其他测定测量-血浆β-内啡肽的测定， 唾液孕酮和CSF DHEAS已经被开发用于研究 IL-2和月经相关的情感变化，以及艾滋病和 老年痴呆症