BEHAVIORAL MEDICINE

行为医学

• 批准号: 3968414
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3968414
• 关键词: behavior disorders; behavioral medicine; case history; cognition disorders; discoid lupus erythematosus; drug adverse effect; gastrointestinal neoplasms; health behavior; hormone therapy; human subject; hyperlipoproteinemia; immunotherapy; interleukin 2; interview; mental disorder diagnosis; pain; pancreas neoplasms; psychological aspect of cancer; psychoneuroimmunology; psychosomatic disorders; steroid hormone; thyroid hormones

Nine protocols are currently active and conducted out of the Consultation-Liaison Service-based behavioral medicine research program. These protocols examine the phenomenology and biological correlates of illness or treatment-induced mood, behavioral, and cognitive changes. The protocols address such areas as: a) the effects of previous psychiatric history on the psychiatric morbidity associated with certain diseases and their treatment; b) the psychiatric phenomenology of certain diseases and their treatment; c) the treatment response characteristics of psychiatric disorders associated with diseases or their treatment; d) biochemical factors that may serve as predictive diagnostic markers for illness or for treatment-associated mood/behavioral or cognitive syndromes; e) the effects of mood state alterations on immunologic function. Significant findings to date include demonstration of a greater than 50% prevalence of interleukin-2-induced behavioral and cognitive changes, the frequent occurrence of endogenous depression as a presenting symptom in cancer of the pancreas compared with gastric cancer, presence of excess psychiatric morbidity in patients with type-5 hyperlipoproteinemia, significant steroid-induced mood alterations in a subset of lupus patients treated with alternate day steroids and normal volunteers treated with acute high-dose steroids, and demonstration of some biological similarity between chest pain and panic disorder patients with respect to their tendency to become symptomatic during lactate infusion.

目前有九项议定书正在执行， 咨询联络服务为基础的行为医学研究计划。 这些协议研究的现象学和生物学相关性， 疾病或治疗引起的情绪、行为和认知变化。 的 协议涉及以下领域：a）以前的精神病的影响 与某些疾病相关的精神病发病史， 他们的治疗; B）某些疾病的精神病学现象， （c）精神病患者的治疗反应特征 与疾病或其治疗相关的病症; d）生物化学 这些因素可能作为疾病的预测诊断标志物， 治疗相关的情绪/行为或认知综合征; e）影响 情绪状态改变对免疫功能的影响。 重大发现， 数据包括证明超过50%的患病率， 白细胞介素-2诱导的行为和认知变化， 内源性抑郁症的发生作为癌症的一种表现症状， 胰腺癌与胃癌相比，存在过多的精神 5型高脂蛋白血症患者的发病率， 类固醇诱导的一组狼疮患者的情绪改变 隔日类固醇和正常志愿者接受急性高剂量 类固醇，并证明胸部之间的一些生物相似性 疼痛和恐慌症患者的倾向， 乳酸盐输注期间出现症状。