HORMONAL STUDIES OF AFFECTIVE DISORDERS

情感障碍的荷尔蒙研究

• 批准号: 5202749
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5202749
• 关键词: cerebrospinal fluid; clinical depression; cortisol; developmental genetics; endorphins; gender difference; gene expression; glutamate decarboxylase; glutamate receptor; hippocampus; hormone regulation /control mechanism; human subject; human tissue; in situ hybridization; laboratory rat; mood disorders; neuroendocrine system; neurogenesis; nimodipine; psychobiology; receptor binding; receptor expression; serotonin receptor; somatostatin; testosterone

Studies of somatostatin, cortisol and beta-endorphin in relation to affective and other neuropsychiatric disorders have continued. Additionally, in vitro hybridization studies have been performed to determine the effects of gonadal steroids on receptor ontogeny. Findings consist of the following: Somatostatin - 1) Patients with depression no longer show decreased CSF somatostatin relative to depressed patients during the euthymic state; both groups, however, show decreased CSF somatostatin relative to normal controls. 2) Increased CSF somatostatin continues to be seen in an expanded group of patients following treatment with nimodipine. In situ - The following have been observed: 1) Sexual dimorphism in the expression of 5-HT1A receptor transcripts and in the binding of 5-HT2 receptors in the hippocampus. 2) Decreased expression of the transcript for the alpha-1 subunit of the glutamate receptor in animals who are conflict trained and increased expression of the transcript for the alpha-2 subunit of glutamate receptor in yoked controls. 3) Acute alterations of the expression of the GABA synthetic enzyme glutamic acid decarboxylase (GAD) in rat brain following perinatal testosterone injection. 4) Evidence of the persistence of EP10 transcription in areas of the rat and bird brains believed to be sites of neurogenesis in the adult animals.

生长抑素、皮质醇和β-内啡肽与脑梗死关系的研究 情感障碍和其他神经精神障碍仍在继续。 此外，还进行了体外杂交研究， 确定性腺类固醇对受体个体发育的影响。 结果 包括： 生长抑素-1）抑郁症患者不再显示CSF降低 正常心境状态下抑郁患者的生长抑素水平; 然而，两组均显示CSF生长抑素相对于正常组降低， 对照 2)CSF生长抑素增加持续见于 尼莫地平治疗后扩大组。 原位--观察到以下现象：1） 5-HT 1A受体转录物的表达和5-HT 2 海马体中的受体。 2)转录本表达减少 谷氨酸受体的α-1亚单位， 冲突训练和增加表达的成绩单， 谷氨酸受体α 2亚单位。 3)急性 GABA合成酶谷氨酸表达的改变 围产期睾酮对大鼠脑内GAD的影响 注射 4)在大鼠脑皮层区域中EP 10转录持续存在的证据 鸟类的大脑被认为是成年鸟类神经发生的场所 动物