PSYCHOBIOLOGY AND TREATMENT OF PERI-MENOPAUSAL MOOD DISORDERS

围绝经期情绪障碍的心理生物学和治疗

• 批准号: 3859996
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859996
• 关键词: cardiovascular disorder; depression; estrogens; female; human subject; human tissue; interview; luteinizing hormone; menopause; mood disorders; neuroendocrine system; ovary disorder; postmenopause; psychobiology; psychosomatic disorders

The goals of this project are to detect and accurately describe peri- menopausal mood disorders, explore their pathophysiology and response to pharmacological and environmental manipulation, and to document the relationship between reproductive endocrine change and disorders of mood as a way of further investigating the neurobiology of psychiatric illness. Findings to date include the following: 1) an absence of ovarian dysfunction in 24% of 93 women presenting with histories of menstrual cycle irregularity; 2) an absence of difference of prevalence of adverse life events in those peri-menopausal women with depression alone compared with those with hot flushes alone; 3) no differences in basal or standard LH bioactive: immunoactive ratios across groups; 4) significant elevations of bioactive LH in the menopausal groups only; 5) preliminary evidence of this efficacy of estrogen in the treatment of climacteric mood disorders without somatic symptomatology.

该项目的目标是检测和准确描述的... 更年期情绪障碍，探讨他们的病理生理和反应， 药理学和环境操作，并记录 生殖内分泌变化与情绪障碍的关系 一种进一步研究精神疾病的神经生物学的方法。 迄今为止的发现包括以下几点：1）缺乏卵巢 在93名有月经周期史的妇女中，24%的妇女出现功能障碍 不规则性; 2）不良生活发生率无差异 仅患有抑郁症的围绝经期妇女的事件与 仅有潮热的患者; 3）基础或标准LH无差异 各组间生物活性：免疫活性比率; 4） 仅在绝经组中有生物活性LH; 5）初步证据表明， 雌激素治疗更年期情绪障碍的疗效 体细胞学