PSYCHOBIOLOGY AND TREATMENT OF MENSTRUALLY-RELATED MOOD DISORDERS

心理生物学和月经相关情绪障碍的治疗

• 批准号: 5203645
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/5203645
• 关键词: acetylcholine; cortisol; endocrine pharmacology; estrogens; female; fluoxetine; gonadotropin releasing factor; hormone regulation /control mechanism; hormone therapy; human subject; human therapy evaluation; memory; menstrual cycle; mental disorder chemotherapy; mood disorders; peptide hormone analog; premenstrual syndrome; progesterone; psychobiology; psychopharmacology; reproductive system disorder chemotherapy

The goals of this project are to detect and accurately describe menstrually-related mood disorders, explore their pathophysiology and response to pharmacological and environmental manipulation, and to document the relationship between reproductive endocrine change and disorders of mood as a way of further investigating the neurobiology of psychiatric illness. In the past year we have identified: 1) the efficacy of the GnRH analogue (Lupron) in a group of 20 patients with premenstrual syndrome; 2) a differential susceptibility to the mood destabilizing effects of gonadal steroids in patients with a history of premenstrual syndrome compared with controls; 3) preliminary evidence of the absence of a mood destabilizing effect of placebo in the hormone replacement phase of the Lupron protocol; 4) elimination of Wisconsin Card Sort-stimulated activation of regional cerebral blood flow by Lupron, with restoration of normal activation by estrogen or progesterone; 5) blunted m-CPP-stimulated cortisol secretion in the luteal phase and ACTH secretion in both menstrual cycle phases in women with PMS compared with controls; 6) absence of effect of Lupron or steroid replacement on immune response to immune stimulation with recall antigen; 7) lack of reversal of efficacy of fluoxetine by tryptophan depletion in five patients with PMS; 8) increased concentration of Gi and ADP ribosylation in ten controls during estrogen replacement compared with the agonadal state; 9) preliminary evidence of enhanced memory performance during progesterone replacement relative to estrogen replacement; 10) preliminary evidence of the stability of the pattern of symptoms of PMS across multiple menstrual cycles.

该项目的目标是检测并准确描述 与月经相关的情绪障碍，探索其病理生理学和 对药理学和环境操纵的反应，以及 记录生殖内分泌变化与 情绪障碍作为进一步研究神经生物学的一种方式 精神疾病。 在过去的一年里，我们确定了：1） GnRH 类似物（Lupron）在 20 名患有以下疾病的患者中的疗效 经前综合症; 2）对情绪的敏感性不同 性腺类固醇对有性病史的患者的不稳定作用 与对照组相比经前综合症； 3）初步证据 激素中不存在安慰剂的情绪不稳定作用 Lupron 方案的替代阶段； 4）消除威斯康星州 卡片分类刺激局部脑血流的激活 亮丙瑞林，通过雌激素或恢复正常激活 黄体酮; 5) 减弱 m-CPP 刺激的皮质醇分泌 女性两个月经周期阶段的黄体期和 ACTH 分泌 经前综合症 (PMS) 与对照组相比； 6) 缺乏亮丙瑞林的作用或 类固醇替代对免疫刺激免疫反应的影响 抗原; 7) 色氨酸不能逆转氟西汀的功效 5 名经前综合症患者的能量消耗； 8) 增加Gi浓度和 雌激素替代期间十个对照的 ADP 核糖基化比较 与性欲状态； 9）增强记忆力的初步证据 黄体酮替代期间相对于雌激素的表现 替代品; 10) 模式稳定性的初步证据 跨多个月经周期的经前综合症症状。