EVALUATION OF MICROENCAPSULATION AS A MEANS TO ADMINISTER CHEMICALS IN FEED

微胶囊化是一种用来包裹挥发性物质或化学物质的过程 淀粉微球中的活性化合物使其长期毒性 可以进行喂养研究，以克服潜在的适口性 有问题。微胶囊化肉桂醛在饲料中的应用研究 与雄性F344大鼠化学灌胃给药相比， B6C3F1小鼠雌雄同源。适口性没有受到影响，而且有毒。 出现了体重、器官重量和组织损伤等反应 在啮齿类动物中，无论接触途径如何，表明 微胶囊可以用来取代成本更高、成本更低的 长期研究中灌胃给药的理想途径。更高 在微胶囊化后可以利用剂量的肉桂醛， 从而最大限度地检测到潜在的有毒或 致癌反应。这些研究将用于确定目标 器官毒性，并通过喂养选择长期研究的剂量 微囊化的化学物质，假定这条首选路线 可以利用管理。

Microencapsulation is a process used to enclose volatile or chemically reactive compounds in starch microspheres so that long-term toxicity feeding studies can be conducted and to overcome potential palatability problems. Studies with microencapsulated cinnamaldehyde in feed were compared with chemical administration by gavage in male F344 rats and both sexes of B6C3F1 mice. Palatability was unaffected and toxic responses such as body and organ weight and tissue lesions occurred in the rodents, irrespective of route of exposure, indicating that microencapsulation could be used to replace the more costly and less desirable route of gavage administration in long-term studies. Higher doses of cinnamaldehyde could be utilized after microencapsulation, resulting in maximization of the detection of potential toxic or carcinogenic responses. These studies will be used to determine target organ toxicity, and to select doses for longer-term studies by feeding the microencapsulated chemical, presuming this preferred route of administration can be utilized.