EVALUATION OF MICROENCAPSULATION AS A MEANS TO ADMINISTER CHEMICALS IN FEED

微胶囊作为饲料中化学品管理手段的评估

• 批准号: 3777446
• 负责人: M P DIETER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3777446
• 关键词: aldehydes; alternatives to animals in research; animal food; chemical carcinogen; chemical carcinogenesis; dosage; drug administration routes; female; food flavor; laboratory mouse; laboratory rat; male; microcapsule; toxicology; toxin metabolism

Microencapsulation is a process used to enclose volatile or chemically reactive compounds in starch microspheres so that long-term toxicity feeding studies can be conducted and to overcome potential palatability problems. Studies with microencapsulated cinnamaldehyde in feed were compared with chemical administration by gavage in male F344 rats and both sexes of B6C3F1 mice. Palatability was unaffected and toxic responses such as body and organ weight and tissue lesions occurred in the rodents, irrespective of route of exposure, indicating that microencapsulation could be used to replace the more costly and less desirable route of gavage administration in long-term studies. Higher doses of cinnamaldehyde could be utilized after microencapsulation, resulting in maximization of the detection of potential toxic or carcinogenic responses. These studies will be used to determine target organ toxicity, and to select doses for longer-term studies by feeding the microencapsulated chemical, presuming this preferred route of administration can be utilized.

微胶囊化是一种用于封装挥发性或化学性物质的过程。 活性化合物的淀粉微球，使长期毒性 可以进行饲养研究，并克服潜在的适口性 问题 研究了微胶囊化肉桂醛在饲料中的应用 与雄性F344大鼠灌胃化学品给药相比， B6C3F1小鼠的两种性别。 适口性未受影响，但具有毒性 出现了诸如体重和器官重量以及组织病变等反应 在啮齿类动物中，无论接触途径如何，表明 微胶囊可以用来取代更昂贵和更少的 长期研究中理想的灌胃给药途径。 更高 微胶囊化后可以使用一定剂量的肉桂醛， 导致对潜在的有毒或有害物质的检测最大化， 致癌反应。这些研究将用于确定目标 器官毒性，并通过喂养选择长期研究的剂量 微胶囊化的化学品，假设这种优选的途径， 可以使用管理。