课题基金 / 基金详情

OXIMES RESEARCH PROJECT

OXIMES RESEARCH PROJECT
肟研究项目
批准号：
3855861
负责人：
M P DIETER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3855861
关键词：
alcohols bone marrow exam chemical carcinogen chemical carcinogenesis drug metabolism environmental toxicology oximes toxin metabolism water pollution

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相关文献

中文摘要
翻译
来自肟类化学品的代表性化合物被提名。 因为它们的毒性和潜在的致癌性尚未被 很好的特点。环己酮肟的接触毒性研究 和丁酮肟在其他地方也有报道。此外，内部研究 环己酮肟和丁酮肟对环境影响的研究 乙二醇烷基醚毒性为阴性，尽管有报道称 肟可能会干扰酒精的新陈代谢。没有更多的内部 预计将进行关于肟的研究，除非共同的 一种对骨髓细胞具有潜在毒性的代谢物在 正在进行的新陈代谢研究和对数据的审查，证明了进一步 调查。
英文摘要
Representative compounds from the oxime class of chemicals were nominated by NCI because their toxicity and potential carcinogenicity had not been well characterized. The contract toxicity studies of cyclohexanone oxime and butanone oxime are reported elsewhere. In addition, in-house research investigations of the influence of cyclohexanone oxime or butanone oxime on glycol alkyl ether toxicity were negative, even though it was reported that oximes might interfere with alcohol metabolism. No further in-house research studies with the oximes are anticipated, unless a common metabolite with potential toxicity to bone marrow cells is identified in ongoing metabolism studies, and review of the data, justifies further investigation.
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