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OXIMES RESEARCH PROJECT

OXIMES RESEARCH PROJECT
肟研究项目
批准号：
3855861
负责人：
M P DIETER
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3855861
关键词：
alcohols bone marrow exam chemical carcinogen chemical carcinogenesis drug metabolism environmental toxicology oximes toxin metabolism water pollution

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中文摘要
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英文摘要
Representative compounds from the oxime class of chemicals were nominated by NCI because their toxicity and potential carcinogenicity had not been well characterized. The contract toxicity studies of cyclohexanone oxime and butanone oxime are reported elsewhere. In addition, in-house research investigations of the influence of cyclohexanone oxime or butanone oxime on glycol alkyl ether toxicity were negative, even though it was reported that oximes might interfere with alcohol metabolism. No further in-house research studies with the oximes are anticipated, unless a common metabolite with potential toxicity to bone marrow cells is identified in ongoing metabolism studies, and review of the data, justifies further investigation.
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CELLULAR BIOCHEMISTRY STUDIES ON CHEMICAL SELECTED FOR EVALUATION BY NTP
EVALUATION OF CHEMICAL MYELOTOXICITY USING AN IN VIVO LEUKEMIA TRANSPLANT MODEL
EVALUATION OF CHEMICAL MYELOTOXICITY USING AN IN VIVO LEUKEMIA TRANSPLANT MODEL
EVALUATION OF MICROENCAPSULATION AS A MEANS TO ADMINISTER CHEMICALS IN FEED