CELLULAR BIOCHEMISTRY STUDIES ON CHEMICAL SELECTED FOR EVALUATION BY NTP

无机或有机金属和金属络合物的作用是 特别令人感兴趣的是， 水和工业过程，用作抗癌成分 药物及其不同的靶器官毒性。 毒理学 正在对各种选定的金属盐进行研究， 支持和扩展在合同测试设施获得的结果。 测量血液和靶器官水平以确定 金属残留物的处置和稳态浓度。 细胞生化反应提供了敏感的指标， 靶器官毒性通常预示临床体征或 病理学的微观证据。 例子包括汞 抑制胸腺T细胞中的糖酵解酶 具有免疫毒性，镍抑制己糖 粒/巨噬细胞干细胞单磷酸分流酶 与骨髓毒性相关的骨髓细胞。 进一步 目前正在研究二氯二茂钛、二氯二茂钛钠 铬酸盐，铬酸锌钾，羰基铬，和 亚铁氰化铁铵

The effect of inorganic or organic metals and metal complexes is of particular interest because of their prevalence in drinking water and industrial processes, use as constituents in anticancer drugs, and their diverse target organ toxicities. Toxicological studies of various, selected metallic salts are being conducted to support and extend the results obtained at contract test facilities. Blood and target organ levels are measured to determine the disposition and steady state concentrations of the metal residues. Cellular biochemical responses provided sensitive indices of target organ toxicity that often preceeded clinical signs or microscopic evidence of pathology. Examples included mercury inhibition of glycolytic enzymes in thymic T-cells in association with immunotoxicity, and nickel inhibition of hexose monophosphate shunt enzymes in granulocyte/macrophage stem cells from bon marrow in association with myelotoxicity. Further studies are underway with titanocene dichloride, sodium chromate, zinc potassium chromate, chromium carbonyl, and ferric ammonium ferrocyanide.