EVALUATION OF MICROENCAPSULATION AS A MEANS TO ADMINISTER CHEMICALS IN FEED

微胶囊作为饲料中化学品管理手段的评估

• 批准号: 3855818
• 负责人: M P DIETER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3855818
• 关键词: animal food; dosage; drug administration routes; food flavor; laboratory mouse; laboratory rat; microcapsule; terpenes

Microencapsulation is a process for enclosing small particles in a protective coating, and is being utilized for administration of chemicals that are volatile or chemically reactive, and to minimize potential problems with unpalatable materials. Studies with microencapsulated citral in rats and mice have shown that palatability was unaffected and that appropriate parameters of toxicity were unaffected by use of the microencapsulated chemical. Studies are underway to compare the toxicity of the material by gavage with the data from the microencapsulation study, pursuant to further 90 day studies. Data from these short-term studies will be evaluated and an appropriate route and doses selected for 2-year studies, if required.

微胶囊化是将小颗粒包裹在微胶囊中的过程 保护涂层，用于化学品管理 具有挥发性或化学反应性，并尽量减少潜在的 材料不好吃的问题。 微囊柠檬醛的研究 在大鼠和小鼠中表明适口性不受影响 适当的毒性参数不受使用的影响 微胶囊化学品。 正在进行研究以比较毒性 根据微胶囊研究的数据通过强饲法对材料进行灌胃， 根据进一步的 90 天研究。这些短期研究的数据将 进行评估并选择 2 年的适当途径和剂量 研究，如果需要的话。