CELLULAR BIOCHEMISTRY STUDIES ON CHEMICAL SELECTED FOR EVALUATION BY NTP

无机或有机金属和金属络合物的作用是 特别令人感兴趣的是， 水和工业过程，用作抗癌成分 和抗蠕虫药物，以及它们不同的靶器官 毒性 各种选定金属的毒理学研究 盐正在进行支持和扩展的结果 在合同测试设施获得。 血液和靶器官 测量水平以确定处置和稳态 金属残留物的浓度。 细胞生化 反应提供了靶器官毒性的敏感指标， 通常预示着临床症状或显微镜证据， 病理 已被研究的金属盐包括汞 氯化物、硫酸镍和二氯化二茂钛。 进一步 正在研究铬酸钠，铬酸锌钾， 和羰基铬的遗传毒性， 不同六价盐的骨髓毒性作用。 的影响 20天腹腔注射对微核、骨髓干细胞 增殖率和细胞生物化学的影响 进行。 研究了不同浓度的苯甲酸钠在大鼠体内的吸收和毒性。 有机铁盐，二茂铁和亚铁氰化铁铵， 正在启动。

The effect of inorganic or organic metals and metal complexes is of particular interest because of their prevalence in drinking water and industrial processes, use as constituents in anticancer and antihelminthic drugs, and their diverse target organ toxicities. Toxicological studies of various, selected metallic salts are being conducted to support and extend the results obtained at contract test facilities. Blood and target organ levels are measured to determine the disposition and steady state concentrations of the metal residues. Cellular biochemical responses provided sensitive indices of target organ toxicity that often preceeded clinical signs or microscopic evidence of pathology. Metal salts that have been studied include mercuric chloride, nickel sulfate, and titanocene dichloride. Further studies are underway with sodium chromate, zinc potassium chromate, and chromium carbonyl in female mice to compare the genotoxic and myelotoxic effects of the different hexavalent salts. The effects of 20-day i.p. injections on micronuclei, on bone marrow stem cell proliferation rates, and on cellular biochemistry are being conducted. Studies of the absorption and toxicity of the organoferric salts, ferrocene and ferric ammonium ferrocyanide, are being initiated.