CELLULAR BIOCHEMISTRY STUDIES ON CHEMICAL SELECTED FOR EVALUATION BY NTP

NTP 选定用于评估的化学物质的细胞生物化学研究

• 批准号: 3918625
• 负责人: M P DIETER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3918625
• 关键词: antineoplastics; bone marrow; chemical carcinogenesis; chromium; environmental contamination; environmental toxicology; hematopoiesis; hematopoietic stem cells; immunotoxicity; laboratory mouse; mercury poisoning; metal complex; metal poisoning; nickel; organometallic compounds; water pollution; water supply; zinc

The effect of inorganic or organic metals and metal complexes is of particular interest because of their prevalence in drinking water and industrial processes, use as constituents in anticancer and antihelminthic drugs, and their diverse target organ toxicities. Toxicological studies of various, selected metallic salts are being conducted to support and extend the results obtained at contract test facilities. Blood and target organ levels are measured to determine the disposition and steady state concentrations of the metal residues. Cellular biochemical responses provided sensitive indices of target organ toxicity that often preceeded clinical signs or microscopic evidence of pathology. Metal salts that have been studied include mercuric chloride, nickel sulfate, and titanocene dichloride. Further studies are underway with sodium chromate, zinc potassium chromate, and chromium carbonyl in female mice to compare the genotoxic and myelotoxic effects of the different hexavalent salts. The effects of 20-day i.p. injections on micronuclei, on bone marrow stem cell proliferation rates, and on cellular biochemistry are being conducted. Studies of the absorption and toxicity of the organoferric salts, ferrocene and ferric ammonium ferrocyanide, are being initiated.

无机或有机金属和金属络合物的影响是 特别令人感兴趣的是它们在饮酒中的普遍程度 水和工业过程，用作抗癌成分 和抗寄生虫药物，以及它们不同的靶器官 毒物。多种精选金属的毒理学研究 为了支持和扩大这一成果，正在进行盐分 在合同测试设施中获得。血液和靶器官 测量水平以确定配置和稳定状态 金属残留物浓度。细胞生化 反应提供了靶器官毒性的敏感指标 通常先于临床症状或微观证据 病理学。已经研究过的金属盐包括汞 氯化物、硫酸镍和二氯化钛。进一步 目前正在研究铬酸钠、铬酸锌、铬酸钾、 和羰基铬在雌性小鼠体内比较遗传毒性和 不同六价盐的骨髓毒性效应。其影响 20天的ip。骨髓干细胞微核注射 增殖率和细胞生化方面的研究 指挥。黄曲霉毒素的吸收和毒性研究 有机铁盐，二茂铁和亚铁氰化铁铵，是 被启动了。