OXIMES RESEARCH PROJECT

肟研究项目

• 批准号: 3876891
• 负责人: M P DIETER
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3876891
• 关键词: alcoholism /alcohol abuse; body weight; bone marrow exam; chemical carcinogen; chemical carcinogenesis; environmental contamination; environmental toxicology; hematology; laboratory mouse; laboratory rat; methemoglobin; nutrient drug interaction; oximes; toxin metabolism; water pollution

The oximes are used in a variety of applications that include intermediates for the production of chemicals and pesticides, blocking agents in the polymer industry, chelator in the metal industry, additives in fuels, dyes, etc., and as biocides for water and waste treatment. Representative compounds from this class of chemicals were nominated by NCI because their toxicity and potential carcinogenicity had not been well characterized. Cyclohexanone oxime and butanone oxime studies were initiated in a contract laboratory to evaluate toxicity in F344 rats and B6C3F1 mice after 14 day and 90 day exposure to the chemicals in the drinking water. Variables that will be measured include body weight, organ weights, clinical signs of toxicity, after the completion of comparative metabolism studies. In addition, preliminary investigations of the influence of cyclyohexamone oxime on glycol alkyl ether toxicity are underway, because this oxime interferes with alcohol metabolism.

肟用于各种应用，包括中间体 用于生产化学品和农药， 聚合物工业，金属工业中的螯合剂，燃料添加剂，染料， 等等，以及用作水和废物处理的杀生物剂。 代表 这类化合物被NCI提名，因为它们 毒性和潜在致癌性尚未得到很好的表征。 环己酮肟和丁酮肟的研究是在一份合同中开始的。 实验室评价14天后F344大鼠和B6C3F1小鼠的毒性 90天暴露于饮用水中的化学物质。 的变量 将测量包括体重、器官重量、 毒性，在完成比较代谢研究后。 在 此外，环己酮的影响的初步调查， 肟对乙二醇烷基醚的毒性正在进行中，因为这种肟 干扰酒精代谢。