FGF RECEPTOR EXPRESSION IN TUMORS

我们分析了肿瘤细胞系中成纤维细胞生长因子受体的表达。我们的结果 提示Flg-Flg受体和碱性成纤维细胞生长因子可能参与了 横纹肌肉瘤的自分泌刺激。同样，我们的结果 提示Flg-成纤维细胞生长因子受体和酸性成纤维细胞生长因子可能参与了 神经胶质瘤的自分泌刺激。表情模式或这个 受体与第二个成纤维细胞生长因子受体BEK显著不同。这个 这两种受体的作用差异尚不清楚。近期 有证据表明，Flg-Fgf受体也是HSV1受体。 这种表达模式对成纤维细胞生长因子受体的研究和 作为确定HSV感染潜在部位的一种手段。

We analyzed tumor cell lines for FGF receptor expression. Our results indicate that the FLG-FLG receptor and basic FGF may be involved in autocrine stimulation in rhabdomyosarcomas. Similarly, our results indicate that the FLG-FGF receptor and acidic FGF may be involved in autocrine stimulation in glial tumors. The expression pattern or this receptor differs significantly from a second FGF receptor BEK. The difference in the roles of these two receptors remains unclear. Recent evidence indicates that the FLG-FGF receptor is also the HSV 1 receptor. The pattern of expression is a value both for the FGF receptor studies and as a means of determining potentialsites of HSV infection.