NEURON-SPECIFIC ENOLASE IN CHILDHOOD TUMORS

儿童肿瘤中的神经元特异性烯醇酶

• 批准号: 3939199
• 负责人: T J TRICHE
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939199
• 关键词: Ewing's tumor; antibody; central nervous system neoplasms; child (0-11); epithelioma; histochemistry /cytochemistry; human tissue; immunochemistry; lymphoma; molecular oncology; neoplasm /cancer diagnosis; neuroblastoma; neurons; pediatric neoplasm /cancer; phosphopyruvate hydratase; prognosis; rhabdomyosarcoma; sarcoma

The diagnosis, and thus therapy, of solid tumors of childhood is often difficult due to lack of distinguishing characteristics. This is especially true of Ewing's sarcoma, neuroblastoma, primitive soft tissue sarcomas, and (occasionally) lymphoma. We have evaluated the presence of a specific neuronal enzyme, neurone- specific enolase (NSE), in paraffin-embedded sections of a diverse group of solid childhood tumors, including previously unrecognized variants of neural tumors, employing immunocytochemistry with antisera to NSE. We find uniform reactivity of all neural tumors with this antibody. No cross- reactivity with non-neural tumors, save a rare example of differentiated rhabdomyosarcoma, was found. We conclude that NSE is a reliable, readily detected marker in even primitive childhood tumors of neural origin. Also, we have defined the neural histogenesis of a newly described, "round cell" tumor of chest wall resembling Ewing's sarcoma, the so-called Askin tumor, which in reality is a form of peripheral neuroepithelioma. Finally, we have recently confirmed the unique character of so- called peripheral neuroepithelioma, which is NSE-positive but which displays hybrid neural and Schwannian morphologic characteristics.

儿童期实体瘤的诊断和治疗方法