MONOCLONAL ANTIBODIES TO EWING'S SACOMA

尤因氏肉瘤单克隆抗体

• 批准号: 3963076
• 负责人: T J TRICHE
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3963076
• 关键词: Ewing's tumor; human subject; monoclonal antibody; neoplasm /cancer immunodiagnosis; neoplasm /cancer immunotherapy; pediatric neoplasm /cancer

This is a new project, just commencing. Extensive studies of Ewing's sarcoma and related round cell tumors of childhood have served to distinguish most from one another on the basis of positive reactivity with one or more antibodies. No antibody specific for Ewing's sarcoma, or restricted to a few tumors including Ewing's, has been identified to date. It is the aim of the present study to produce a battery of monoclonal antibodies against selected, well-characterized Ewing's sarcoma lines established in this laboratory. They will then be studied and compared in their reactivity with other monoclonal antibodies previously reported. Any antibody found to be strongly reactive with Ewing's sarcoma cells will be further characterized, with the eventual intention to use same as a potential diagnostic, imaging, and therapeutic tool.

这是一个新项目，刚刚开始。 对尤因的广泛研究 肉瘤和相关的圆细胞肿瘤的儿童已服务， 基于与以下物质的阳性反应性， 一种或多种抗体。 无尤文氏肉瘤特异性抗体，或 仅限于少数肿瘤，包括尤因氏肿瘤，迄今已被确定。 本研究的目的是生产一组单克隆抗体， 针对选定的、充分表征的尤文肉瘤系的抗体 建立在这个实验室里。 然后，他们将被研究和比较， 它们与先前报道的其它单克隆抗体的反应性。 任何 发现与尤文氏肉瘤细胞强烈反应的抗体将被 其进一步特征在于，最终意图是将其用作 潜在的诊断、成像和治疗工具。