MONOCLONAL ANTIBODIES TO EWING'S SACOMA

这是一个新项目，刚刚开始。对…的广泛研究 儿童尤文肉瘤和相关的圆形细胞瘤 用于在以下基础上将大多数区分开来 与一种或多种抗体呈阳性反应。无抗体 专用于尤文氏肉瘤，或仅限于少数肿瘤 包括尤因的，到目前为止已经被确认。它的目标是 本研究旨在制备一系列单抗 针对选定的、特征良好的尤因肉瘤株 在这个实验室建立的。然后将对它们进行研究和 与其他单抗的反应性比较 之前报道过。任何被发现具有强烈反应的抗体 尤因肉瘤细胞的进一步特征， 最终的意图是将其用作潜在的诊断， 成像和治疗工具。

This is a new project, just commencing. Extensive studies of Ewing's sarcoma and related round cell tumors of childhood have served to distinguish most from one another on the basis of positive reactivity with one or more antibodies. No antibody specific for Ewing's sarcoma, or restricted to a few tumors including Ewing's, has been identified to date. It is the aim of the present study to produce a battery of monoclonal antibodies against selected, well-characterized Ewing's sarcoma lines established in this laboratory. They will then be studied and compared in their reactivity with other monoclonal antibodies previously reported. Any antibody found to be strongly reactive with Ewing's sarcoma cells will be further characterized, with the eventual intention to use same as a potential diagnostic, imaging, and therapeutic tool.