MONOCLONAL ANTIBODIES TO EWING'S SACOMA

尤因氏肉瘤单克隆抗体

• 批准号: 3939351
• 负责人: T J TRICHE
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939351
• 关键词: Ewing's tumor; human subject; monoclonal antibody; neoplasm /cancer immunodiagnosis; neoplasm /cancer immunotherapy; pediatric neoplasm /cancer

This is a new project, just commencing. Extensive studies of Ewing's sarcoma and related round cell tumors of childhood have served to distinguish most from one another on the basis of positive reactivity with one or more antibodies. No antibody specific for Ewing's sarcoma, or restricted to a few tumors including Ewing's, has been identified to date. It is the aim of the present study to produce a battery of monoclonal antibodies against selected, well-characterized Ewing's sarcoma lines established in this laboratory. They will then be studied and compared in their reactivity with other monoclonal antibodies previously reported. Any antibody found to be strongly reactive with Ewing's sarcoma cells will be further characterized, with the eventual intention to use same as a potential diagnostic, imaging, and therapeutic tool.

这是一个新项目，刚刚开始。 广泛研究 尤文氏肉瘤和相关的儿童圆形细胞肿瘤， 他们中的大多数人，都是以自己为基础， 与一种或多种抗体呈阳性反应。 无抗体 对尤文氏肉瘤有特异性，或仅限于少数肿瘤 包括尤因的，已经被确认了 它的目的是 本研究旨在生产一系列单克隆抗体， 针对选定的、特征明确的尤文肉瘤细胞系， 建立在这个实验室里。 他们将被研究， 与其他单克隆抗体相比， 此前报道。 任何发现具有强烈反应性的抗体 与尤文肉瘤细胞将进一步表征， 最终意图是将其用作潜在的诊断， 成像和治疗工具。