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N-MYC EXPRESSION IN SMALL ROUND CELL TUMORS OF CHILDHOOD

N-MYC EXPRESSION IN SMALL ROUND CELL TUMORS OF CHILDHOOD
儿童小圆细胞肿瘤中 N-MYC 的表达
批准号：
3916390
负责人：
T J TRICHE
金额：
$0.0万
依托单位：
DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3916390
关键词：
gene expression human tissue immunochemistry laboratory rabbit monoclonal antibody natural gene amplification neoplasm /cancer genetics neoplasm /cancer immunodiagnosis neuroblastoma oncogenes pediatric neoplasm /cancer prognosis

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英文摘要
N-myc oncogene expression is an important factor in neuroblastoma prognosis and biologic behavior. N-myc has been sporadically reported in rare other childhood tumors. Further antibody detection methods have recently become available. We have used a rabbit polyclonal antibody to detect the N-myc protein in tissue sections of the common tumors of childhood. We have further correlated these results with conventional Northern, Southern, and Western analysis of examples of each of these tumors. We find no evidence of N-myc amplification, expression, or protein accumulation in any of these tumors save neuroblastoma.
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