EXTRACELLULAR MATRIX SYNTHESIS BY HUMAN TUMORS IN VITRO

人类肿瘤的体外细胞外基质合成

• 批准号: 3962894
• 负责人: T J TRICHE
• 金额: --
• 依托单位: DIVISION OF CANCER BIOLOGY AND DIAGNOSIS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3962894
• 关键词: Ewing's tumor; autoradiography; carcinoma; cell differentiation; cellular oncology; extracellular matrix; fibroblasts; fibrosarcoma; gel electrophoresis; human tissue; immunofluorescence technique; neoplasm /cancer classification /staging; neoplasm /cancer genetics; neoplasm /cancer immunodiagnosis; neoplastic cell; neoplastic growth; radiotracer; tissue /cell culture

The type and amount of matrix proteins synthesized by human tumor cells in vitro appears to parallel that of cultured normal cell counterparts to some extent. We have broadened these observations to a variety of human tumors to determine whether these patterns might allow more precise categorization of the tumor's origins. In addition, we are characterizing a new matrix protein synthesized by some of these tumors. The identity, function, and molecular organization within the extracellular matrix of this component is currently unknown.

人肿瘤细胞合成的基质蛋白的种类和数量 体外培养的正常细胞似乎与某些 范围。我们已经将这些观察扩大到各种人类肿瘤 以确定这些模式是否可以进行更精确的分类 肿瘤的起源。此外，我们正在描述一种新的矩阵 由其中一些肿瘤合成的蛋白质。身份、功能和 该组分的细胞外基质中的分子组织是 目前尚不清楚。