EFFECT OF CHRONIC SUBCUTANEOUS OR INTRAMURAL ADMINISTRATION OF HEPARIN

长期皮下或壁内给予肝素的影响

• 批准号: 3843443
• 负责人: W C ROBERTS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843443
• 关键词: angiography; artery stenosis; atherosclerotic plaque; cardiovascular disorder chemotherapy; cholesterol; disease /disorder model; drug administration routes; heparin; intraarterial administration; intraluminal angioplasty; laboratory rabbit; nonhuman therapy evaluation; nutrition related tag; pathogenic diet

Heparin is known to have antithrombotic, anticoagulant, and antiproliferative effects. We hypothesized that chronic subcutaneous and/or direct intramural administration of heparin would reduce restenosis and inhibit plaque growth following balloon angioplasty. Focal atherosclerosis was induced bilaterally in the femoral arteries of 59 rabbits by air desiccation intimal injury and a 2% cholesterol diet. After angioplasty, the rabbits were assigned to one of four treatment groups. Control arteries (n=21) received no additional heparin. A second group of 20 arteries was treated with a porous balloon which delivered heparin (1500 U) directly into the arterial wall. A third group (n=29) received subcutaneous heparin (350 U/kg/day) for 28 days, and a fourth group (n=23) was treated with subcutaneous and intramural heparin. Chronic subcutaneous heparin after balloon angioplasty results in a modest reduction in angiographic restenosis in this model, however, the absolute luminal diameter is not improved compared with pre-angioplasty and plaque area and percent luminal narrowing by plaque were not different among the four treatment groups. Heparin can be delivered into an atherosclerotic plaque using a porous balloon, but this treatment does not reduce restenosis after angioplasty in this model.

已知肝素具有抗血栓形成、抗凝血和抗血小板聚集作用。 抗增殖作用。 我们假设慢性皮下 和/或肝素的直接壁内给药将减少再狭窄 并抑制球囊血管成形术后的斑块生长。 焦 在59名受试者的股动脉中诱导双侧动脉粥样硬化 空气干燥内膜损伤和2%胆固醇饲料。 在血管成形术后，兔子被分配到四个治疗组之一， 组 对照动脉（n=21）未接受额外肝素。 第二 一组20支动脉用多孔球囊治疗， 将肝素（1500 U）直接注入动脉壁。 第三组（n=29） 皮下注射肝素（350 U/kg/天）28天，第四组 肝素组（n=23），皮下注射肝素和肌壁注射肝素。 球囊血管成形术后慢性皮下肝素导致中度 然而，在该模型中，血管造影再狭窄的绝对减少 与血管成形术前和斑块相比，管腔直径没有改善 斑块引起的管腔狭窄面积和百分比在不同的 四个治疗组。 肝素可以被输送到动脉粥样硬化 使用多孔球囊治疗斑块，但这种治疗不会减少 血管成形术后再狭窄。