CONGENITALLY QUADRICUSPID AORTIC VALVE--ANALYSIS OF 6 NECROPSY PATIENTS

先天性四瓣主动脉瓣--6例尸检患者分析

• 批准号: 3920141
• 负责人: W C ROBERTS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920141
• 关键词: aortic valve disorder; congenital heart disorder; congenital heart septum defect; coronary artery; heart dimension /size; histopathology; human tissue; mitral valve; pathology; postmortem; prosthetic heart valve

Congenitally quadricuspid aortic valves are rare and usually cause no valvular dysfunction. We studied 6 patients with quadricuspid aortic valves. One quadricuspid aortic valve was severely regurgitant, necessitating surgical replacement. The 5 remaining valves functioned normally and each of these 5 patients died from a non-cardiac condition. Other congenital cardiac abnormalities were present in 2 of the 6 patients: case 1 had a "ventricular septal defect" which had closed spontaneously and case 2 had a congenitally deficient posterior one half of the anterior mitral leaflet and no attached chordae tendineae to it. The accessory cusp in all 6 patients was smaller than any of the other 3 cusps which were similar in size. The accessory cusp was between the right and posterior cusps in 4 patients, between the left and posterior cusps in case 1, and between the right and left cusps in case 2. The right coronary artery was dominant in the 5 patients in whom coronary dominance was known.

先天性四叶主动脉瓣是罕见的，通常会导致 没有瓣膜功能障碍 我们研究了6例四尖瓣 主动脉瓣 一个四叶主动脉瓣严重 不稳定，需要手术置换。 其余5例 瓣膜功能正常，这5例患者均死于 非心脏病 其他先天性心脏畸形 6例患者中有2例存在：病例1有“心室 例2为自发性关闭的“间隔缺损”，例2为自发性关闭的“间隔缺损”，例3为自发性关闭的“间隔缺损”。 先天性二尖瓣前叶后半部分缺损 瓣叶和没有附着腱索。附件 所有6例患者的瓣尖均小于其他3个瓣尖中的任一个 大小相似 副瓣尖位于 4例患者的右尖和后尖，在左尖和后尖之间， 例1的后尖，例2的右尖和左尖之间， 案例2. 右冠状动脉占优势5例 冠状动脉优势是已知的。