ATHEROSCLEROTIC PLAQUES IN SUDDEN DEATH AND IN MYOCARDIAL INFARCTION

猝死和心肌梗死中的动脉粥样硬化斑块

• 批准号: 3858089
• 负责人: W C ROBERTS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3858089
• 关键词: atherosclerosis; atherosclerotic plaque; coronary artery; human subject; human tissue; myocardial infarction; postmortem; sudden cardiac death

We studied at necropsy atherosclerotic plaque composition in the 4 major (right, left main, left anterior descending, and left circumflex) epicardial coronary arteries in 15 patients who died of consequences of an acute myocardial infarction (AMI) and in 12 patients with sudden coronary death (SCD) with AMI. Within the AMI group and within the SCD group, there were no differences in plaque composition among any of the four major epicardial coronary arteries. Within both groups, plaque morphology varied as a function of cross-sectional-area narrowing of the segments. In both groups, the amount of dense relatively acellular fibrous tissue, calcified tissue, and pultaceous debris increased in a linear fashion with increasing degrees of cross-sectional-area narrowing of the segments, and the amount of cellular fibrous tissue decreased linearly. In the AMI group, the percentage of plaque consisting of pultaceous debris and of cellular fibrous tissue separated significantly narrowed (>75% cross-sectional area) segments from less narrowed (<75%) segments. A comparison of the AMI group to the SCD group showed significant differences.

我们在尸检时研究了4个主要动脉粥样硬化斑块的组成， （右、左主干、左前降支和左回旋支） 心外膜冠状动脉的15例患者， 急性心肌梗死（AMI）和12例突然 冠状动脉死亡（SCD）伴AMI。 在AMI组和SCD组内 组中，任何一个组之间的菌斑组成没有差异。 四条心外膜冠状动脉 在两组中，斑块 形态变化的横截面积缩小的功能， 片段 在这两组中，致密的相对非细胞的量 纤维组织、钙化组织和粉质碎片在一个月内增加， 横截面积变窄程度增加的线性方式 节段的细胞纤维组织数量减少， 线性地。 在AMI组中， 牙垢碎片和细胞纤维组织明显分离 狭窄（>75%横截面积）节段与较不狭窄（<75%）节段 片段 AMI组与SCD组的比较显示， 显著差异。