FREQUENCY OF RUPTURE OF THE LEFT VENTRICULAR FREE WALL OR VENTRICULAR SEPTUM

左心室游离壁或心室隔膜破裂的频率

• 批准号: 3899223
• 负责人: W C ROBERTS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3899223
• 关键词: cardiovascular disorder epidemiology; coronary intensive care; heart septum; human tissue; literature survey; myocardial infarction; pathology

Review of 18 publications before the widespread use of cardiac care units disclosed that the frequency of rupture of the left ventricular free wall or ventricular septum among necropsy cases of acute myocardial infarction ranged from 4 to 24% (mean 8%) (619 of 7905 cases). We analyzed the frequency of rupture of the left ventricular free wall or ventricular septum among patients studied at necropsy in our laboratory since 1968 with fatal acute myocardial infarction. Of 648 such patients, 204 (31% had rupture of the left ventricular free wall or ventricular septum. Rupture occurred in 171 (40%) of 431 patients without healed myocardial infarcts (grossly visible left ventricular scars), and in 29 (13%) of 217 patients with a healed myocardial infarct (p<.Ol). Thus, the frequency of rupture of the left ventricular free wall of ventricular septum during acute myocardial infarction appears to have increased substantially since the widespread use of coronary care units, and the frequency of rupture is nearly 3 times greater in those in whom rupture occurred during the first acute myocardial infarction compared to those with a previous infarct which healed.

在广泛使用心脏监护病房之前对18篇出版物的回顾 揭示了左心室游离壁破裂的频率 急性心肌梗死尸检病例中， 范围为4 - 24%（平均8%）（619/7905例）。我们分析了 左心室游离壁或心室壁破裂的频率 自1968年以来，我们实验室在尸检时研究的患者中， 致命的急性心肌梗死在648例此类患者中，204例（31%） 左心室游离壁或室间隔破裂。破裂 在431例未治愈的心肌梗死患者中，171例（40%）发生 （左心室瘢痕肉眼可见），217例患者中有29例（13%） 心肌梗塞愈合（p<0.01）。因此， 急性期左室间隔游离壁 心肌梗死似乎大幅增加，因为 冠状动脉监护病房的广泛使用，以及破裂的频率是 在第一次破裂期间发生破裂的患者中， 急性心肌梗死与既往心肌梗死相比， 好了