HYPERTROPHIC CARDIOMYOPATHY AS A CAUSE OF MASSIVE CARDIOMEGALY

正常成年人的心脏重量，女性≤ 350克，男性≤ 400克 G.人类心脏重量>1000 g的情况极为罕见。 在过去的30年里，大约有10,000名成年人的心脏， 各种类型的心血管疾病已经在这方面进行了检查， 实验室其中，30只体重>1000 g。最常见的（15 大心脏肥大的原因是主动脉瓣返流， 或没有其他体积病变，如二尖瓣返流，或 室间隔缺损压迫性损伤是导致大面积 心脏肥大远不常见：4例患者患有主动脉瓣狭窄，但 所有患者还伴有主动脉瓣返流或二尖瓣返流。 心肌病是一种罕见的原因，巨大的心脏。>200例患者 在尸检中研究了特发性扩张型心肌病， 在实验室中，没有心脏重量>1000 g。在70例心脏病患者中， 淀粉样变性广泛到足以引起心脏功能障碍，没有人有巨大的 心脏肥大在过去的30年里，我们在尸检220 肥厚型心肌病（HC）200例，其中200例 岁的在后一个数字中，8个心脏重量>1000 g。因此，在本发明中， HC需要被添加到大面积心脏肥大的原因列表中。什么 导致我们的8名患者出现巨大心脏肥大的原因尚不清楚。

The normal adult human heart in women weighs <or = 350g and in men, <or 400 g. The occurrence of heart weights in humans >1000 g is exceedingly rare. During the past 30 years, approximately 10,000 human adult hearts with various types of cardiovascular diseases have been examined in this laboratory. Of that number, 30 weighed >1000 g. The most common (15 patients) cause of the massive cardiomegaly was aortic regurgitation with or without other volume lesions, such as mitral regurgitation or ventricular septal defect. Pressure lesions as the cause of massive cardiomegaly was far less common: 4 patients had aortic valve stenosis, but all also had associated aortic regurgitation or mitral regurgitation. Cardiomyopathy is a rare cause of massive cardiomegaly. Of >200 patients with idiopathic dilated cardiomyopathy studied at necropsy in this laboratory, none had hearts weighing >1000 g. Of 70 patients with cardiac amyloidosis extensive enough to cause cardiac dysfunction, none had massive cardiomegaly. During the past 30 years, we have studied at necropsy 220 patients with hypertrophic cardiomyopathy (HC) and 200 of them were >20 years of age. Of this latter number, 8 had hearts weighing >1000 g. Thus, HC needs to be added to the list of causes of massive cardiomegaly. What led to the massive cardiomegaly in our 8 patients is unclear.