MODES OF DEATH, FREQUENCY OF HEALED AND ACUTE MYOCARDIAL INFARCTS

死亡模式、治愈率和急性心肌梗塞

• 批准号: 3899226
• 负责人: W C ROBERTS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3899226
• 关键词: atherosclerosis; coronary occlusion /thrombosis; disease /disorder classification; heart dimension /size; human mortality; myocardial ischemia /hypoxia; pathology; postmortem; wound healing

Modes of death, frequency of a healed or an acute myocardial infarct (MI) or both, numbers of major epicardial coronary arteries severely narrowed by atherosclerotic plaque, and heart weight were studied at necropsy in 889 patients aged 30 years of age or older with fatal atherosclerotic coronary artery disease (CAD). No patient had had a coronary bypass operation or coronary angioplasty. The 889 patients were divided into 4 major groups and each major group was divided into 2 subgroups: 1) acute MI without (306 patients) and with (119 patients) a healed MI; 2) sudden out-of-hospital death without (121 patients) and with (118 patients) a healed MI; 3) chronic congestive heart failure (CHF) with a healed MI without (137 patients) and with (33 patients) a left ventricular aneurysm; and 4) sudden in-hospital death without (20 patients) or with (35 patients) unstable angina pectoris. The mean age of the 687 men (77%) was 60 + 11 years. and of the 202 women (23%), 68 + 13 years (p=.0001). Of the patients studied, 53% had systemic hypertension, 39% angina pectoris, and 33% diabetes mellitus. Of the 880 patients, 415 (48%) had 1 or more grossly visible left ventricular scars. Over half (51%) of the 889 patients had 3 or 4 (includes left main) major epicardial coronary arteries narrowed >75% in cross-sectional area by atherosclerotic plaque. The mean heart weight in the men was 505 + 110 g, and in the 202 women, 427 + 94 & (normal in men <400 g; in women, <350 g) (P=.0001), and only 20% of the patients had a heart of normal weight.

死亡方式、治愈或急性心肌梗死(MI)的频率 或两者兼而有之，主要心外膜冠状动脉的数量严重狭窄 对889例尸检的动脉粥样硬化斑块和心脏重量进行了研究。 30岁或以上的致命性动脉粥样硬化性冠状动脉病变患者 动脉疾病(CAD)。没有患者接受过冠状动脉搭桥手术或 冠状动脉血管成形术。 889例患者被分成4个主要组，每个主要组 分为2个亚组：1)无急性心肌梗死306例，急性心肌梗死伴急性心肌梗死119例 患者)治愈的心肌梗死；2)院外猝死(121 患者)和(118例)治愈的心肌梗死；3)慢性充血性心脏 心力衰竭(CHF)，无(137例)和(33例)心肌梗死治愈 患者)左室壁瘤；4)住院猝死 无不稳定型心绞痛(20例)或伴不稳定型心绞痛(35例)。这个 687名男性(77%)的平均年龄为60+11岁。在202名女性中 (23%)，68年+13年(p=0.0001)。在被研究的患者中，53%的患者有全身性 高血压、39%的心绞痛和33%的糖尿病。在880人中 415名患者(48%)有1个或更多明显的左心室疤痕。 在889名患者中，超过一半(51%)的患者有3或4个(包括左主干)主干 心外膜冠状动脉横截面积变窄75% 动脉粥样硬化斑块。男性的平均心脏重量为505±110克， 而在202名女性中，427+94&(正常男性为400克，女性为350克) (P=0.0001)，只有20%的患者心脏重量正常。