LOCATION OF AN AMI IN PATIENTS WITH A HEALED INFARCT

梗死已愈合患者中 AMI 的位置

• 批准号: 3920142
• 负责人: W C ROBERTS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920142
• 关键词: acute disease /disorder; atherosclerosis; cardiovascular disorder epidemiology; heart disorder diagnosis; histopathology; human tissue; myocardial infarct sizing; myocardial infarction; pathology; postmortem

To determine the relation of a single healed myocardial infarct to a fatal acute myocardial infarct we studied 129 patients at necropsy with 1 grossly visible healed and 1 grossly visible acute infarct, and determined whether the acute infarct was opposite to or adjacent to the healed infarct or if one infarct was so large that it was both opposite to and adjacent to the other infarct. In 74 (57%) of the 129 patients, the 2 infarcts were opposite one another, in 40 (31%) they were adjacent, and in 15 (12%) they were both opposite and adjacent. The age, sex, mean size of the healed infarct and heart weight were similar among the 3 groups. Acute myocardial infarcts were larger in the group that had both opposite and adjacent infarcts than either of the other 2 groups (P<0.001). Information regarding whether the infarcts were clinically recognized or not was available in 108 patients: both infarcts were recognized in 41 (38%), neither infarct was recognized in 15 (14%), and 1 infarct was recognized and the other was not in 52 (48%). The number of the 4 major epicardial coronary arteries narrowed at some point >75% in cross-sectional area by atherosclerotic plaque was similar in patients with recognized and in those with unrecognized infarcts. Similar numbers of narrowed major epicardial coronary arteries also were found in each of the 3 infarct groups (opposite, adjacent or both).

为了确定单个治愈的心肌梗死与 我们研究了129名患者， 尸检，1例肉眼可见愈合，1例肉眼可见急性 梗死，并确定急性梗死是否与 或邻近已愈合的梗死灶，或如果一个梗死灶太大， 它与另一个梗死灶既相对又相邻。 129例患者中有74例（57%）的2个梗死灶与另一个梗死灶相反 40例（31%）相邻，15例（12%） 既相对又相邻。 治愈者的年龄、性别、平均身高 梗死和心脏重量在3组之间相似。 急性 心肌梗死在两组中均相反， 与其他两组相比，梗死灶周围区的梗死面积明显减少（P<0.001）。 关于梗死是否在临床上 在108例患者中， 41例（38%）被识别，15例未被识别 (14 52例中1例梗死被识别，另1例未被识别 (48%). 4条主要心外膜冠状动脉的数量 在横截面积中的某个点处变窄>75%， 动脉粥样硬化斑块在识别和 在那些未被发现的梗死患者中。 相似数量的缩小 主要的心外膜冠状动脉也被发现在每个 3个梗死组（对侧、相邻或两者）。