DIAGNOSIS AND CD5+ BETA CELLS IN PSYCHIATRIC PATIENTS

精神病患者的诊断和 CD5 Beta 细胞

• 批准号: 3845381
• 负责人: D GLOVINSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3845381
• 关键词: B lymphocyte; CD5 molecule; autoimmune disorder; biomarker; human subject; mental disorder diagnosis; schizophrenia

The CD5+ beta-lymphocyte subpopulation, which has been linked to several autoimmune diseases, has been reported to be increased in a subset of schizophrenic patients. To test the specificity of this finding, we measured the CD5+ beta-lymphocyte percentage of total lymphocytes in blood samples from 81 community mental health center patients and 10 controls. Results were analyzed according to diagnosis. The CD5+ beta-cell percentage in the substance abuser group was significantly elevated in comparison to all other groups. The percentage in the schizophrenic group was higher than the control group, but this increase was not statistically significant.

CD5+β淋巴细胞亚群，它与几个 自身免疫性疾病，据报道在以下子集中增加 精神分裂症患者。为了测试这一发现的特异性，我们 检测外周血中CD5+β淋巴细胞占总淋巴细胞的百分比 81名社区精神卫生中心患者和10名患者的血液样本 控制。结果按诊断法进行分析。CD5+ 物质滥用组中的β细胞百分比显著 与所有其他群体相比都处于较高水平。所占百分比 精神分裂症组高于对照组，但这一增加 在统计学上并不显著。