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SCREENING BRAIN DNA FOR HTLV-1 PROVIRAL SEQUENCES USING PCR AMPLIFICATION

SCREENING BRAIN DNA FOR HTLV-1 PROVIRAL SEQUENCES USING PCR AMPLIFICATION
使用 PCR 扩增筛选脑 DNA 中的 HTLV-1 原病毒序列
批准号:
3845273
负责人:
D GLOVINSKY
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
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中文摘要
翻译
聚合酶链反应(PCR)扩增已用于鉴定
英文摘要
Polymerase chain reaction (PCR) amplification has been used to identify retrovirus-like sequences in both multiple sclerosis patients and non-neurologic control patients. Having used PCR to identify novel endogenous retrovirus-like sequence in human brain DNA, we are now defining its tissue distribution and transcriptional activity. Genomic DNA was extracted from 12 autopsied brains patients with multiple sclerosis and from 8 without MS. PCR amplification of the DNA was performed, and radiolabeled fragments of cloned sequences were used to probe DNA complementary to RNA from different human organs., as well as from various animals. No correlation between PCR amplification and MS was found. The DNA insert cloned from PCR amplification products differed from a previously described sequence, and most likely represents an endogenous DNA sequence.
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会议论文
PATIENT RESPONSE TO RESUMPTION OF NEUROLEPTICS FOLLOWING A DRUG FREE INTERVAL
CEREBROSPINAL FLUID OXYTOCIN IN SCHIZOPHRENIC AND CONTROL SUBJECT
PATIENT RESPONSE TO RESUMPTION OF NEUROLEPTIC FOLLOWING A DRUG FREE INTERVAL
SCREENING BRAIN DNA FOR HTLV-1 PROVIRAL SEQUENCES USING PCR AMPLIFICATION
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