SCREENING BRAIN DNA FOR HTLV-1 PROVIRAL SEQUENCES USING PCR AMPLIFICATION

使用 PCR 扩增筛选脑 DNA 中的 HTLV-1 原病毒序列

• 批准号: 3859941
• 负责人: D GLOVINSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859941
• 关键词: genome; human T cell lymphotropic virus type 1; human genetic material tag; human tissue; multiple sclerosis; natural gene amplification; nervous system disorder diagnosis; neurotropic virus; polymerase chain reaction; postmortem; provirus; virus DNA; virus classification

Multiple sclerosis (MS) is a chronic demyelinating disease of unknown cause. Attempts to link the retrovirus human T-cell lymphotropic virus I (HTLV-I) to MS have been made by the demonstration of DNA sequences in peripheral blood leukocytes of MS patients that show sequence homology to the HTLV-I genome. We have continued to investigate the finding of such sequences in post mortem brain tissue and control subjects.

多发性硬化症（MS）是一种慢性脱髓鞘疾病， 事业 尝试将逆转录病毒人类T细胞嗜淋巴细胞病毒I （HTLV-I）到MS的DNA序列的演示已经完成， MS患者的外周血白细胞显示出与 HTLV-I基因组。 我们继续调查发现这样的序列后， 尸检脑组织和对照组