PATIENT RESPONSE TO RESUMPTION OF NEUROLEPTICS FOLLOWING A DRUG FREE INTERVAL

研究表明，精神分裂症患者对恢复 精神抑制剂的特征模式，但有分歧， 症状改变的机制。 为了澄清这个问题， 双盲，连续测量的行为和症状的变化， 精神分裂症受试者在一次治疗后恢复精神抑制药物治疗， 分析停药期。 百分之五十的反应发生在 到药物恢复后的第七天，包括显著的 改善症状/行为清单分量表测量妄想， 幻觉和其他与精神病相关的阳性症状。

Studies have shown that schizophrenics respond to the reinstatement of neuroleptics in a characteristic pattern, but there is disagreement about the mechanism underlying symptom change. To clarify this issue, double-blind, serial measurements of the behavior and symptom change of schizophrenic subjects who resumed neuroleptic medication after a drug-free period were analyzed. Fifty percent of the response occurred by the seventh day of post-drug reinstatement, including a significant improvement in symptom/behavior inventory subscales measuring delusions, hallucinations, and other positive symptoms associated with psychosis.