PATIENT RESPONSE TO RESUMPTION OF NEUROLEPTICS FOLLOWING A DRUG FREE INTERVAL

患者对停药间隔后恢复神经抑制药的反应

• 批准号: 3845335
• 负责人: D GLOVINSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3845335
• 关键词: antipsychotic agents; behavior prediction; drug administration rate /duration; drug withdrawal; human subject; human therapy evaluation; mental disorder chemotherapy; psychopharmacology; schizophrenia

Studies have shown that schizophrenics respond to the reinstatement of neuroleptics in a characteristic pattern, but there is disagreement about the mechanism underlying symptom change. To clarify this issue, double-blind, serial measurements of the behavior and symptom change of schizophrenic subjects who resumed neuroleptic medication after a drug-free period were analyzed. Fifty percent of the response occurred by the seventh day of post-drug reinstatement, including a significant improvement in symptom/behavior inventory subscales measuring delusions, hallucinations, and other positive symptoms associated with psychosis.

研究表明，精神分裂症患者对恢复 抗精神病药的特征模式，但存在分歧 症状变化的机制。 为了澄清这个问题， 双盲、连续测量行为和症状变化 精神分裂症患者在一次治疗后恢复精神安定药物治疗 分析无药期。 发生了百分之五十的响应 到药物恢复后的第七天，包括显着的 衡量妄想的症状/行为量表的改善， 幻觉和其他与精神病相关的阳性症状。