PATIENT RESPONSE TO RESUMPTION OF NEUROLEPTICS FOLLOWING A DRUG FREE INTERVAL

研究表明，精神分裂症患者对恢复 精神抑制剂的特征模式，但有分歧， 症状改变的机制。 为了澄清这个问题，双... 对行为和症状变化进行盲法连续测量， 精神分裂症受试者在服用药物后恢复精神抑制药物， 分析了空闲时间。百分之五十的反应发生在 药物恢复后第7天，包括显著 改善症状/行为清单分量表测量妄想， 幻觉和其他与精神病相关的阳性症状。

Studies have shown that schizophrenics respond to the reinstatement of neuroleptics in a characteristic pattern, but there is disagreement about the mechanism underlying symptom change. To clarify this issue, double- blind, serial measurements of the behavior and symptom change of schizophrenic subjects who resumed neuroleptic medication after a drug- free period were analyzed. Fifty percent of the response occurred by the seventh day of post-drug reinstatement, including a significant improvement in symptom/behavior inventory subscales measuring delusions, hallucinations, and other positive symptoms associated with psychosis.