SCREENING BRAIN DNA FOR HTLV-1 PROVIRAL SEQUENCES USING PCR AMPLIFICATION

使用 PCR 扩增筛选脑 DNA 中的 HTLV-1 原病毒序列

• 批准号: 3880958
• 负责人: D GLOVINSKY
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3880958
• 关键词: brain; genome; human T cell lymphotropic virus type 1; human tissue; multiple sclerosis; natural gene amplification; nervous system disorder diagnosis; neurotropic virus; nucleic acid probes; polymerase chain reaction; postmortem; provirus; virus DNA; virus classification

Multiple sclerosis (MS) is a chronic demyelinating disease of unknown cause. The retrovirus human T-cell lymphotropic virus I (HTLV-I) has been linked to MS by the demonstration of DNA sequences in peripheral blood leukocytes of MS patients that show sequence homology to the HTLV-I genome. We have continued to investigate the finding of such sequences in post mortem brain tissue of MS and control subjects.

多发性硬化症（MS）是一种慢性脱髓鞘疾病， 事业逆转录病毒人类T细胞嗜淋巴细胞病毒I（HTLV-I）已经被发现。 通过外周血中DNA序列的证明与MS有关 MS患者的白细胞显示与HTLV-I基因组的序列同源性。 我们继续调查后发现的此类序列 MS和对照受试者的尸检脑组织。