ENDOMYOCARDIAL BIOPSY FINDINGS IN LONG-TERM TREATMENT WITH AMIODARONE

胺碘酮长期治疗的心内膜心肌活检结果

• 批准号: 3843451
• 负责人: V J FERRANS
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3843451
• 关键词: amiodarone; biopsy; drug administration rate /duration; drug adverse effect; heart cell; heart disorder chemotherapy; histopathology; human therapy evaluation; human tissue; inclusion body; lysosomes; muscle cells; myocardium disorder; vascular endothelium

This report describes ultrastructural changes in myocardium of 2 patients with dilated cardiomyopathy who had received long term treatment with amiodarone, a highly effective antiarrhythmic agent. Cardiac myocytes and endothelial cells in these two patients contained cytoplasmic inclusions that consisted of electron-dense concentric lamellae and were considered to represent altered lysosomes. These inclusions were morphologically similar to those occurring in other tissues in patients receiving long term therapy with amiodarone.

本报告描述了 2 名患者的心肌超微结构变化 患有扩张型心肌病并接受长期治疗的 胺碘酮，一种高效的抗心律失常药。心肌细胞和 这两名患者的内皮细胞含有细胞质内含物 由电子致密的同心片层组成，被认为 代表改变的溶酶体。 这些内含物形态相似 接受长期治疗的患者其他组织中发生的情况 与胺碘酮。