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ENDOMYOCARDIAL BIOPSY FINDINGS IN LONG-TERM TREATMENT WITH AMIODARONE

ENDOMYOCARDIAL BIOPSY FINDINGS IN LONG-TERM TREATMENT WITH AMIODARONE
胺碘酮长期治疗的心内膜心肌活检结果
批准号：
3843451
负责人：
V J FERRANS
金额：
$0.0万
依托单位：
NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3843451
关键词：
amiodarone biopsy drug administration rate /duration drug adverse effect heart cell heart disorder chemotherapy histopathology human therapy evaluation human tissue inclusion body lysosomes muscle cells myocardium disorder vascular endothelium

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中文摘要
翻译
本文报道了2例患者心肌超微结构的变化。 患有扩张型心肌病，并接受了长期的 胺碘酮，一种高效的抗心律失常药物。心肌细胞和 这两例患者的血管内皮细胞含有胞浆内含物 它由电子致密的同心薄片组成，并被认为 代表改变后的溶酶体。这些包裹体在形态上是相似的 在接受长期治疗的患者中发生在其他组织中的 用胺碘酮。
英文摘要
This report describes ultrastructural changes in myocardium of 2 patients with dilated cardiomyopathy who had received long term treatment with amiodarone, a highly effective antiarrhythmic agent. Cardiac myocytes and endothelial cells in these two patients contained cytoplasmic inclusions that consisted of electron-dense concentric lamellae and were considered to represent altered lysosomes. These inclusions were morphologically similar to those occurring in other tissues in patients receiving long term therapy with amiodarone.
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会议论文
STUDIES OF THE MORPHOLOGY OF THE BIOPROSTHETIC HEART VALVES
SURGICAL PATHOLOGY OF THE CARDIOVASCULAR SYSTEM
ULTRASTRUCTURE AND FUNCTION OF THE MYOCARDIUM--AN OVERVIEW
INTRALUMINAL FIBROSIS IN FIBROTIC LUNG DISORDERS
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