Defining the role of innate T cells in the onset and progression of Chronic Periodontitis

定义先天 T 细胞在慢性牙周炎发生和进展中的作用

• 批准号: nhmrc : 1029878
• 负责人: A/Pr Neil O'Brien-Simpson
• 金额: $ 38.81万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-innate-chronic-periodontitis/110716
• 关键词: Defining; role; innate; cells; onset

Particular immune cell populations (innate T cells), have a critical role in immunity. These cells are stimulated by bacterial cell wall components and are one of the first cells to appear after infection. We have shown that these innate T cells are stimulated by oral bacteria that cause the disease chronic periodontitis. This project will investigate how these innate T cells affect bacterial induced periodontitis and what role they play in disease outcomes.

特定的免疫细胞群（先天性T细胞）在免疫中具有关键作用。这些细胞受到细菌细胞壁成分的刺激，是感染后最先出现的细胞之一。我们已经证明，这些先天性T细胞受到口腔细菌的刺激，导致慢性牙周炎。该项目将研究这些先天性T细胞如何影响细菌诱导的牙周炎，以及它们在疾病结果中发挥什么作用。