A multi-protein vaccine targeting the oral pathogens associated with chronic periodontitis

针对与慢性牙周炎相关的口腔病原体的多蛋白疫苗

• 批准号: nhmrc : 1027819
• 负责人: A/Pr Neil O'Brien-Simpson
• 金额: $ 47.86万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/multi-protein-vaccine-chronic-periodontitis/110595
• 关键词: multi; protein; vaccine; targeting; oral

Periodontitis is a chronic inflammatory disease associated with specific bacteria leading to the destruction of the toothÍs supporting tissues and ultimately tooth loss and is a major public health problem in all societies. Our research is focused on designing a vaccine that targets the major bacteria associated with periodontitis. We aim to produce a triple antigen vaccine and investigate the applicability of a vaccine administered under the tongue as an alternative to needle injections.

牙周炎是一种与特定细菌相关的慢性炎症性疾病，会导致牙齿S支持组织的破坏，最终导致牙齿脱落，是所有社会的主要公共卫生问题。我们的研究重点是设计一种针对与牙周炎相关的主要细菌的疫苗。我们的目标是生产一种三联抗原疫苗，并研究舌下注射疫苗作为针头注射的替代方案的适用性。