Development of site-specific predictive assay for periodontal disease progression using mass spectrometric &RT- PCR Anal

使用质谱法开发牙周病进展的位点特异性预测分析

• 批准号: nhmrc : 219189
• 负责人: A/Pr Neil O'Brien-Simpson
• 金额: $ 10万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-site-specific-pcr-anal/100113
• 关键词: Development; site; specific; predictive; assay

In this project new DNA-based technology will be developed to determine the numbers of specific bacteria in the dental plaque of patients. The project will also use new mass spectrometric analysis techniques for the determination of compounds in gingival crevicular fluid, an exudate from the gums. These two techniques will be used in a clinical trial to determine if periodontal (gum) disease progression can be predicted by changes in the numbers of bacteria or in the composition of gingival crevicular fluid. This could provide insight into the development of periodontal disease and lead to new preventive and treatment regimes.

在该项目中，将开发新的基于 DNA 的技术来确定患者牙菌斑中特定细菌的数量。该项目还将使用新的质谱分析技术来测定龈沟液（牙龈的渗出液）中的化合物。这两种技术将用于临床试验，以确定是否可以通过细菌数量或龈沟液成分的变化来预测牙周（牙龈）疾病的进展。这可以深入了解牙周病的发展并带来新的预防和治疗方案。