Molecular studies of dentine phosphophoryn and development of a biomimetic dental restorative material.

牙本质磷酸化的分子研究和仿生牙科修复材料的开发。

• 批准号: nhmrc : 251707
• 负责人: A/Pr Neil O'Brien-Simpson
• 金额: $ 29.66万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2003
• 资助国家: 澳大利亚
• 起止时间: 2003-01-01 至 2005-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/molecular-studies-dentine-restorative-material/99361
• 关键词: Molecular; studies; dentine; phosphophoryn; development

This project involves the study of a protein that is found in teeth and is responsible for the development of dentine. The project involves characterisation of this protein and its interaction with calcium phosphate mineral using a variety of techniques. The information obtained will allow the synthesis of a peptide that will mimick the function of phosphophoryn. This peptide will be used together with stabilized amorphous calcium phosphate in a novel dental restorative material that will help protect the surrounding tooth tissue.The outcome will be an improved understanding of the design principles used by nature to engineer teeth. The significance is the potential development of biocompatible, superior dental restorative materials.

该项目涉及对牙齿中发现的一种蛋白质的研究，这种蛋白质负责牙本质的发育。该项目涉及使用多种技术表征这种蛋白质及其与磷酸钙矿物质的相互作用。获得的信息将允许合成模拟磷酸蛋白功能的肽。这种肽将与稳定的无定形磷酸钙一起用于新型牙科修复材料，该材料将有助于保护周围的牙齿组织。其结果将是加深对大自然用于工程牙齿的设计原理的理解。其意义在于生物相容性优异的牙科修复材料的潜在开发。