Molecular studies of dentine phosphophoryn and development of a biomimetic dental restorative material.

该项目涉及对牙齿中发现的一种蛋白质的研究，这种蛋白质负责牙本质的发育。该项目涉及使用各种技术表征这种蛋白质及其与磷酸钙矿物质的相互作用。所获得的信息将允许合成肽，其将模拟磷酸蛋白的功能。这种肽将与稳定的无定形磷酸钙一起用于新型牙科修复材料中，有助于保护周围的牙齿组织。其结果将是对自然界用于工程牙齿的设计原理的更好理解。其意义在于开发生物相容性好、上级的牙科修复材料。

This project involves the study of a protein that is found in teeth and is responsible for the development of dentine. The project involves characterisation of this protein and its interaction with calcium phosphate mineral using a variety of techniques. The information obtained will allow the synthesis of a peptide that will mimick the function of phosphophoryn. This peptide will be used together with stabilized amorphous calcium phosphate in a novel dental restorative material that will help protect the surrounding tooth tissue.The outcome will be an improved understanding of the design principles used by nature to engineer teeth. The significance is the potential development of biocompatible, superior dental restorative materials.