Anticariogenic casein phosphopeptide-amorphous calcium fluoride phosphate

防龋酪蛋白磷酸肽-无定形磷酸氟化钙

• 批准号: nhmrc : 209042
• 负责人: A/Pr Neil O'Brien-Simpson
• 金额: $ 27.68万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2002
• 资助国家: 澳大利亚
• 起止时间: 2002-01-01 至 2004-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/anticariogenic-casein-phosphopeptide-fluoride-phosphate/96083
• 关键词: Anticariogenic; casein; phosphopeptide; amorphous; calcium

Dental caries (tooth decay) is initiated by demineralisation of tooth hard tissue by organic acids produced by dental plaque bacteria from dietary sugars. The disease is a major public health problem and has an estimated economic burden in Australia of over $1 billion p.a. being higher than that for any other dietary-related disease. We have discovered and patented a novel amorphous calcium fluoride phosphate that is stabilised by phosphopeptides from the bovine milk protein casein. These complexes, designated CPP-ACFP, have the potential to provide superior clinical efficacy in preventing dental caries and treating and repairing early stages of disease. The aims of this project therefore are (i) to develop topical formulations of CPP-ACFP for application to teeth to repair early stages of decay and (ii) to characterise the three-dimensional structure of the CPP-ACFP complexes. The significance of this work is that a superior and novel treatment for dental caries may be developed as well as providing insight into the structure of organically-stabilised amorphous calcium phosphate and its role in biomineralisation processes.

龋齿（蛀牙）是由牙菌斑细菌从膳食糖产生的有机酸使牙齿硬组织脱矿物质引起的。该疾病是一个主要的公共卫生问题，在澳大利亚每年估计有超过10亿澳元的经济负担。高于其他任何与饮食有关的疾病。我们发现了一种新的无定形磷酸氟化钙并获得专利，这种磷酸氟化钙由牛乳蛋白酪蛋白中的磷酸肽稳定。这些复合物，命名为CPP-ACFP，具有在预防龋齿和治疗和修复疾病的早期阶段中提供上级临床功效的潜力。因此，该项目的目的是（i）开发用于牙齿修复早期龋齿的CPP-ACFP局部制剂，以及（ii）构建CPP-ACFP复合物的三维结构。这项工作的意义在于，可以开发出一种上级和新颖的龋齿治疗方法，并深入了解有机稳定的无定形磷酸钙的结构及其在生物矿化过程中的作用。