Development of antimicrobial peptides targeting oral pathogenic bacteria

针对口腔致病菌的抗菌肽的开发

• 批准号: nhmrc : 1008106
• 负责人: A/Pr Neil O'Brien-Simpson
• 金额: $ 44.23万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/development-antimicrobial-peptides-pathogenic-bacteria/109280
• 关键词: Development; antimicrobial; peptides; targeting; oral

The bacterial associated oral diseases; periodontitis and caries are major public health problems. The prevalence of these diseases and increasing bacterial antibiotic resistance has meant there is a need to develop new therapies. This project addresses this by modifying a novel class of antibiotics/antiseptics �antimicrobial peptides� to target oral bacteria and testing them using a newly developed screening method. This project will lead to new therapies for periodontitis and caries.

细菌相关性口腔疾病，牙周炎和龋齿是主要的公共卫生问题。这些疾病的流行和细菌抗生素耐药性的增加意味着需要开发新的疗法。该项目通过修改一类新的抗生素/防腐剂“抗菌肽”来靶向口腔细菌并使用新开发的筛选方法对其进行测试来解决这一问题。该项目将导致牙周炎和龋齿的新疗法。