Delineating aberrant adaptive immune responses due to germline mutations in the PI3K signalling pathway

描述由于 PI3K 信号通路种系突变导致的异常适应性免疫反应

• 批准号: nhmrc : 1127157
• 负责人: A/Pr Tri Phan
• 金额: $ 66.66万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/delineating-aberrant-adaptive-signalling-pathway/947956
• 关键词: Delineating; aberrant; adaptive; immune; responses

Activation of immune cells is required to generate appropriate immune responses that protect is from disease caused by pathogens. The inability to receive the correct type of signals causes immunodeficiency. The PI3 kinase pathway is central to immune cell activation – and genetic errors in this pathwat compromise the functioning of immune cells. We will investigate the nature of these defects and pursue avenues of overcoming them using pharmacological inhibitors of the PI3K pathway.

需要激活免疫细胞来产生适当的免疫反应，以保护IS免受病原体引起的疾病的侵袭。无法接收正确类型的信号会导致免疫缺陷。PI3激酶途径是免疫细胞激活的中心，而这一途径中的遗传错误会损害免疫细胞的功能。我们将调查这些缺陷的本质，并寻求使用PI3K途径的药理抑制剂来克服它们的方法。