Targeting B cell dynamics in immunity, autoimmunity and cancer

针对免疫、自身免疫和癌症中的 B 细胞动态

• 批准号: nhmrc : GNT1155678
• 负责人: A/Pr Tri Phan
• 金额: $ 64.92万
• 依托单位国家: 澳大利亚
• 项目类别: Research Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-b-cell-autoimmunity-cancer/1349194
• 关键词: Targeting; cell; dynamics; immunity; autoimmunity

B cells keep us healthy by making antibodies that prevent infection. However, B cells can also cause disease when they make autoantibodies that attack our own body, or become cancers such as multiple myeloma. This application plans to use cutting-edge technologies of intravital two-photon microscopy, single cell RNA sequencing and CRISPR/Cas9 gene editing to determine the processes that regulate B cell behaviour and how they become dysregulated in autoimmune diseases and multiple myeloma.

B细胞通过制造抗体来防止感染，从而使我们保持健康。然而，当B细胞产生攻击我们自己身体的自身抗体时，也会引起疾病，或者成为多发性骨髓瘤等癌症。该应用计划使用活体双光子显微镜，单细胞RNA测序和CRISPR/Cas9基因编辑等尖端技术来确定调节B细胞行为的过程以及它们如何在自身免疫性疾病和多发性骨髓瘤中失调。