The role of subcapsular sinus macrophages in lymph node metastases

被膜下窦巨噬细胞在淋巴结转移中的作用

• 批准号: nhmrc : 1004632
• 负责人: A/Pr Tri Phan
• 金额: $ 30.07万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-subcapsular-sinus-node-metastases/109056
• 关键词: role; subcapsular; sinus; macrophages; lymph

This project tackles the problem of lymph node metastases using complementary studies in mouse models and human patients with melanoma. It takes the novel approach of examining the local geographical factors in the lymph node and focusses on a rare cell called the subcapsular sinus macrophage that may be a critical determinant of the clinical outcome. This will result in innovative strategies for primary prevention of not only melanoma but other cancer cell metastases.

该项目利用小鼠模型和人类黑色素瘤患者的互补研究来解决淋巴结转移的问题。它采用了检查淋巴结中局部地理因素的新方法，并专注于一种称为被膜下窦巨噬细胞的罕见细胞，该细胞可能是临床结果的关键决定因素。这将导致创新的策略，不仅对黑色素瘤，但其他癌细胞转移的一级预防。