Myeloma Plasma Cell Dormancy - 'Eradicating the Sleeping Giant'

骨髓瘤浆细胞休眠——“消灭沉睡的巨人”

• 批准号: nhmrc : 1139237
• 负责人: A/Pr Tri Phan
• 金额: $ 56.42万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2020-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/myeloma-plasma-cell-sleeping-giant/1318948
• 关键词: Myeloma; Plasma; Cell; Dormancy; Eradicating

Multiple myeloma is a fatal cancer that develops in the skeleton. Current therapies are initially effective, but patients develop resistance and the disease returns. This makes the search for drugs to overcome resistance a priority. Myeloma cells can hide in bone in a dormant state where they are insensitive to chemotherapy. We have identified new drug targets in dormant cells. We are investigating whether these new targets can be used eradicate myeloma cells and cure the disease.

多发性骨髓瘤是一种在骨骼中发展的致命癌症。目前的治疗方法最初是有效的，但患者会产生耐药性，疾病会复发。这使得寻找克服耐药性的药物成为优先事项。骨髓瘤细胞可以以休眠状态隐藏在骨骼中，在这种状态下，它们对化疗不敏感。我们已经在休眠细胞中发现了新的药物靶点。我们正在研究这些新的靶点是否可以用来根除骨髓瘤细胞并治愈这种疾病。