Dynamic in vivo imaging of molecular and cellular events shaping the immune response in mouse models and human diseases

对影响小鼠模型和人类疾病免疫反应的分子和细胞事件进行动态体内成像

• 批准号: nhmrc : 1005097
• 负责人: A/Pr Tri Phan
• 金额: $ 26.76万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2014-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dynamic-vivo-imaging-human-diseases/109089
• 关键词: Dynamic; vivo; imaging; molecular; cellular

We plan to develop the instruments and associated technologies required to directly visualise biological processes as the occur in real-time deep inside living organisms. Thus we will use two-photon microscopy to provide deep tissue imaging of immune cell interactions in mouse models and confocal endomicroscopy to provide molecular imaging of cancer biomarkers in patients with colorectal cancer.

我们计划开发所需的仪器和相关技术，以直接可视化生物过程，实时深入生物体内。因此，我们将使用双光子显微镜来提供小鼠模型中免疫细胞相互作用的深层组织成像，并使用共聚焦显微内镜来提供结直肠癌患者中癌症生物标志物的分子成像。