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The mechanism for combined immunodeficiency and autoimmunity due to STK4-deficiency and its broader application to human PIDs

The mechanism for combined immunodeficiency and autoimmunity due to STK4-deficiency and its broader application to human PIDs
STK4 缺陷引起的联合免疫缺陷和自身免疫的机制及其在人类 PID 中的更广泛应用
批准号:
nhmrc : 1139865
负责人:
A/Pr Tri Phan
金额:
$43.84万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 2020-12-31

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中文摘要
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英文摘要
Why do some patients develop autoimmune diseases such as lupus where the immune system makes antibodies that attack its own body? To answer this, we plan to study a disease where a gene responsible for making antibodies is defective. Patients with mutations in the STK4 gene are unable to regulate the selection processes by which only the right cell is chosen to make antibodies. Understanding how STK4 works may help us unlock the mystery of what causes lupus.
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Targeting B cell dynamics in immunity, autoimmunity and cancer
  • 批准号:
    nhmrc : GNT1155678
  • 项目类别:
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  • 资助金额:
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  • 财政年份:
    2019
  • 负责人:
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The mechanism for combined immunodeficiency and autoimmunity due to STK4-deficiency and its broader application to human PIDs
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    nhmrc : GNT1139865
  • 项目类别:
    Project Grants
  • 资助金额:
    $64.84万
  • 财政年份:
    2018
  • 负责人:
    A/Pr Tri Phan
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Myeloma Plasma Cell Dormancy - 'Eradicating the Sleeping Giant'
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  • 财政年份:
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  • 负责人:
    A/Pr Tri Phan
  • 依托单位:
Myeloma Plasma Cell Dormancy - 'Eradicating the Sleeping Giant'
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    nhmrc : 1139237
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  • 财政年份:
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国内基金
海外基金
“合金标准”下测量误差校正模型及其在体育运动数据中的应用
  • 批准号:
    10801133
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    17.0万元
  • 批准年份:
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  • 负责人:
    张三国
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