The mechanism for combined immunodeficiency and autoimmunity due to STK4-deficiency and its broader application to human PIDs
The mechanism for combined immunodeficiency and autoimmunity due to STK4-deficiency and its broader application to human PIDs
批准号:
nhmrc : GNT1139865
负责人:
A/Pr Tri Phan
金额:
$64.84万
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2018
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2018-01-01 至 --
中文摘要
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英文摘要
Why do some patients develop autoimmune diseases such as lupus where the immune system makes antibodies that attack its own body? To answer this, we plan to study a disease where a gene responsible for making antibodies is defective. Patients with mutations in the STK4 gene are unable to regulate the selection processes by which only the right cell is chosen to make antibodies. Understanding how STK4 works may help us unlock the mystery of what causes lupus.
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The mechanism for combined immunodeficiency and autoimmunity due to STK4-deficiency and its broader application to human PIDs
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依托单位: