STUDIES ON EPSTEIN-BARR VIRUS AND HIV

爱泼斯坦-巴尔病毒和艾滋病毒的研究

• 批准号: 3939630
• 负责人: D ABLASHI
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3939630
• 关键词: AIDS; Epstein Barr virus; Herpesvirus saimiri; antibody formation; cancer risk; fibroblasts; human immunodeficiency virus 1; human middle age (35-64); human tissue; immunofluorescence technique; lymphoma; neoplasm /cancer genetics; neoplasm /cancer immunology; oncogenic virus; serotyping; tissue /cell culture; viral carcinogenesis; virus antigen; virus genetics; virus related neoplasm /cancer; virus replication

Acquired immunodeficiency syndrome (AIDS) B-cell lymphomas occur in individuals in the 30-year age group with a history of homosexuality, bisexuality, and intravenous drug use. Thirty percent of these lymphomas are, histologically, Burkitt's type and contain the Epstein-Barr virus (EBV) genome. The other B-cell lymphomas are diffuse, large cell type which lack EBV association. Based on these findings, the interaction of EBV, possible other human viruses, and HIV in B-cell lymphomas was investigated. B-cell lymphomas associated with EBV developed in an HIV-virus- positive and antibody-positive AIDS patient six months after significant increase in EBV-early antigen antibody (EA) titers were observed. This suggested that EBV may lead to polyclonal proliferation of B-cells, one of which may undergo transformation. During the course of these investigations, a novel human B lymphotropic virus (HBLV) was isolated from peripheral blood lymphocytes from two AIDS patients with B-cell lymphomas. Later on, HBLV was also isolated from four patients with angioimmunoblastic lymphoadenopathy, immunoblastic lymphoma, and lymphocytic leukemia. HBLV is a new herpesvirus which is genetically and immunologically distinct from known herpesviruses.

获得性免疫缺陷综合征 (AIDS) B 细胞淋巴瘤 发生于有以下病史的 30 岁年龄段的个体 同性恋、双性恋和静脉注射毒品。 三十 从组织学角度来看，这些淋巴瘤的百分比属于 Burkitt 型， 含有 Epstein-Barr 病毒 (EBV) 基因组。 另一个B细胞 淋巴瘤是弥漫性大细胞类型，缺乏 EBV 协会。 基于这些发现，EBV 的相互作用， 可能还有其他人类病毒，B细胞淋巴瘤中的HIV 调查了。 与 EBV 相关的 B 细胞淋巴瘤是在 HIV 病毒中形成的 阳性且抗体阳性的艾滋病患者六个月后 EBV 早期抗原抗体 (EA) 滴度显着增加 被观察到。 这表明 EBV 可能导致多克隆 B 细胞增殖，其中之一可能会发生 转变。 在这些调查过程中，一种新型人类 B 从外周血中分离出嗜淋巴细胞病毒（HBLV） 来自两名患有 B 细胞淋巴瘤的艾滋病患者的淋巴细胞。 随后，又从四名患者体内分离出 HBLV。 血管免疫母细胞性淋巴结病、免疫母细胞性淋巴瘤、 和淋巴细胞白血病。 HBLV是一种新型疱疹病毒 在遗传和免疫学上与已知的不同 疱疹病毒。