HUMAN HERPESVIRUS-6 (HHV-6), EPSTEIN-BARR VIRUS (EBV) AND HIV STUDIES

人类疱疹病毒 6 (HHV-6)、爱泼斯坦-巴尔病毒 (EBV) 和 HIV 研究

• 批准号: 3874620
• 负责人: D ABLASHI
• 金额: --
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3874620
• 关键词: AIDS; B lymphocyte; CD4 molecule; Epstein Barr virus; Herpesviridae disease; Hodgkin's disease; RNA directed DNA polymerase; Sjogren's syndrome; T lymphocyte; antiviral antibody; cancer risk; chronic fatigue syndrome; helper T lymphocyte; human herpesvirus 6; human immunodeficiency virus 1; human immunodeficiency virus 2; human tissue; immunofluorescence technique; immunoglobulin M; in situ hybridization; leukocyte activation disorder; leukocyte antigen typing; leukopenia; lymphoma; mononucleosis; neoplasm /cancer genetics; neoplasm /cancer immunology; nucleic acid probes; oncogenic virus; sarcoidosis; serotyping; systemic lupus erythematosus; thyroiditis; tissue /cell culture; transposon /insertion element; viral carcinogenesis; virus DNA; virus antigen; virus cytopathogenic effect; virus envelope; virus infection mechanism; virus related neoplasm /cancer; virus replication; virus virus interaction

Fifteen HHV-6 isolates from normal donors, patients with immunodeficiency syndromes, systemic lupus erythematosus (SLE). atypical polyclonal lymphoproliferation (APL), leukopenia and Exanthum subitum revealed biological, immunological and molecular differences which may be important for seroepidemiological and other immunovirological studies. Active HHV-6 infection was observed in patients with APL, AIDS, Sjogren's syndrome. Hodgkin's disease, chronic fatigue syndrome, SLE and some transplant patients, based on reactivities of HHV-6 monoclonal antibodies with lymphocytes from the patients, presence of IgM antibody to HHV-6 and significant elevation in IgG antibody. Reactivation of HHV-6 may contribute to immune disturbances, either by interfering with function of immunocytes or by polyclonal stimulation of T-cells, which, in turn, lead to disease manifestations.

15株HHV-6分离自正常供体，免疫缺陷患者