人类疱疹病毒 6 (HHV-6)、爱泼斯坦-巴尔病毒 (EBV) 和 HIV 研究-猫眼课题宝

人类疱疹病毒 6 (HHV-6)、爱泼斯坦-巴尔病毒 (EBV) 和 HIV 研究

批准号：

3874620

负责人：

D ABLASHI

金额：

$0.0万

依托单位：

DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3874620

关键词：

AIDS B lymphocyte CD4 molecule Epstein Barr virus Herpesviridae disease Hodgkin's disease RNA directed DNA polymerase Sjogren's syndrome T lymphocyte antiviral antibody cancer risk chronic fatigue syndrome helper T lymphocyte human herpesvirus 6 human immunodeficiency virus 1 human immunodeficiency virus 2 human tissue immunofluorescence technique immunoglobulin M in situ hybridization leukocyte activation disorder leukocyte antigen typing leukopenia lymphoma mononucleosis neoplasm /cancer genetics neoplasm /cancer immunology nucleic acid probes oncogenic virus sarcoidosis serotyping systemic lupus erythematosus thyroiditis tissue /cell culture transposon /insertion element viral carcinogenesis virus DNA virus antigen virus cytopathogenic effect virus envelope virus infection mechanism virus related neoplasm /cancer virus replication virus virus interaction

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英文摘要

Fifteen HHV-6 isolates from normal donors, patients with immunodeficiency syndromes, systemic lupus erythematosus (SLE). atypical polyclonal lymphoproliferation (APL), leukopenia and Exanthum subitum revealed biological, immunological and molecular differences which may be important for seroepidemiological and other immunovirological studies. Active HHV-6 infection was observed in patients with APL, AIDS, Sjogren's syndrome. Hodgkin's disease, chronic fatigue syndrome, SLE and some transplant patients, based on reactivities of HHV-6 monoclonal antibodies with lymphocytes from the patients, presence of IgM antibody to HHV-6 and significant elevation in IgG antibody. Reactivation of HHV-6 may contribute to immune disturbances, either by interfering with function of immunocytes or by polyclonal stimulation of T-cells, which, in turn, lead to disease manifestations.

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