HORMONAL STUDIES OF AFFECTIVE DISORDER

情感障碍的荷尔蒙研究

• 批准号: 3944618
• 负责人: D R RUBINOW
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944618
• 关键词: Alzheimer's disease; blood brain barrier; cerebellar cortex; cerebrospinal fluid; clinical chemistry; cognition disorders; cortisol; hormone regulation /control mechanism; human subject; interleukin 2; mental disorder chemotherapy; messenger RNA; neuroendocrine system; neuropsychological tests; neuropsychology; neurotoxins; pituitary adrenal axis; psychophysiology; psychotropic drugs; somatostatin

Studies of somatostatin and cortisol in relation to affective and other neuropsychiatric disorders have continued. Additionally, further studies of the mechanisms of interleukin-2-induced neurotoxicity have been performed in rodents. A) Somatostatin - CSF somatostatin has been measured in an expanded group of neuropsychiatric patients including patients with multiple sclerosis and neurological controls, patients with alcoholism, pathological gambling, and Huntington's dementia. Significant correlations were observed between somatostatin and performance on the Weschsler Memory Scale, supporting our earlier observations (and perhaps the clinical relevance) of decreased somatostatin levels in patients with neuropsychiatric disorders characterized by cognitive impairment. Studies of the regional concentrations of brain somatostatin in post-mortem schizophrenics, suicide victims, and accident victims have been completed with the sample code not yet broken. B) Cortisol - A salivary cortisol method, developed and validated in our laboratory, has been used to longitudinally follow patients with affective and anxiety disorders. This method shows great promise for studies of ambulatory patients with affective disorder. B) Interleukin-2 - No changes in blood-brain-barrier permeability were observed in rats treated with interleukin-2, irrespective of the size of the tracer employed. These findings contradict previous reports and leave unresolved the mechanism of lymphokine-induced neurotoxicity.

生长抑素和皮质醇与情绪和行为的关系 其他神经精神疾病仍在继续。 此外，本发明还 白细胞介素-2诱导细胞凋亡机制的进一步研究 在啮齿类动物中进行了神经毒性试验。 A）生长抑素- CSF生长抑素已经在一个受试者中测量。 扩大的神经精神病患者组，包括 多发性硬化症和神经控制，患者 酗酒病态赌博和亨廷顿痴呆症 生长抑素与生长激素水平之间存在显著相关性， Weschsler记忆量表上的表现，支持我们的 早期的观察结果（以及可能的临床相关性） 神经精神病患者的生长抑素水平降低 以认知障碍为特征的疾病。 的研究 死后脑内生长抑素的局部浓度 精神分裂症患者，自杀受害者和事故受害者已经被 完成了示例代码，但还没有被破坏。 B）皮质醇-一种唾液皮质醇方法，已开发和验证 在我们的实验室中，已被用于纵向跟踪患者 情感和焦虑障碍 这种方法显示出巨大的 对患有情感障碍的非卧床患者进行研究的前景 disorder. B）白细胞介素-2-血脑屏障通透性无变化 在用白细胞介素-2治疗的大鼠中观察到， 所用示踪剂的大小。 这些发现与 以前的报告和悬而未决的机制， 淋巴因子诱导的神经毒性。